A smaller average reference changed SOZ power AUROC in 15-second excerpts from 36 public SEEG recordings

We tested reference sensitivity in two 15-second windows from 36 public SEEG recordings. The source was OpenNeuro ds004100 version 1.1.3. Each reduced reference retained half the named groups, rounded up. Both references were tested on the same retained contacts. In the primary 70 to 110 Hz band, the mean participant median absolute SOZ AUROC change was 0.0134. Its 95 percent participant bootstrap interval was 0.0090 to 0.0193. The mean participant median rank correlation was 0.9894. The mean participant fraction of valid sets with an absolute AUROC change of at least 0.05 was 0.0892. Typical changes were modest, with larger changes in some sets. The package contains code, covariance data, source hashes, figures, and reproduction instructions. The short excerpts do not establish clinical benefit or long-term stability.

stereoelectroencephalography · SEEG · common-average reference · spectral power · seizure onset zone · AUROC · reference sensitivity