In 36 HUP SEEG patients, longer epilepsy duration was not associated with a larger SOZ or more non-SOZ spiking; the high-gamma contrast did not pass Holm correction

We tested a pre-registered prediction of the network-expansion hypothesis: the seizure-onset zone (SOZ) is larger or more distinct after a longer epilepsy duration. Duration is age minus age at onset in ds004100 participants.tsv. We used 36 HUP SEEG patients with archived per-pair interictal features (f717daf8) from two independent clips. Five Spearman tests used the patient as the unit, with permutation p values, bootstrap CIs and Holm correction. The SOZ fraction of pairs (rho -0.02, 95% CI -0.37 to 0.35), the number of SOZ shafts (-0.05) and the fraction of non-SOZ pairs with spiking (-0.01) did not change with duration. The spike-rate SOZ AUC did not change (-0.19). The 65-115 Hz power SOZ AUC decreased with duration (rho -0.37, p 0.025, Holm p 0.13). It was weaker in the second clip (-0.24, p 0.16), so the rule does not accept it. Control for age and implant size did not change these results. The test can find only |rho| >= ~0.45. The package contains the code, the plan hash, the input hashes and the per-patient tables.

epilepsy · stereo-EEG · seizure-onset zone · interictal activity · epilepsy duration · high-gamma power · OpenNeuro ds004100 · Spearman correlation