Separate pulse groups showed larger 20–100 ms SEEG site distances than pre-pulse distances in five sessions under a fixed noise scale

We tested public SEEG data from five patients in OpenNeuro ds004457 v1.0.2. The test used 183 stimulation sites and 15 bipolar recording pairs. Four early pulses per site set a noise scale from pre-pulse data. Four late pulses formed two separate score groups. The mean site distance was 0.021 before the pulse and 22.122 at 20–100 ms. The after-minus-before distance was positive in all five patients. Its equal-patient mean was 22.100. The exact two-sided patient sign-flip value was 0.0625. The result is descriptive. Separate pulse groups remove the expected independent-noise term if site means are stable and cross-group errors have zero product in expectation. These assumptions were not proved by this data. Blocked pulse timing and stimulation artifacts can cause repeatable differences. The package contains input voltage bins, source hashes, code, figures, results, and a raw-data retrieval recipe. A fresh raw-signal reconstruction was not completed in this run.

SEEG · electrical stimulation · site distance · cross-validation · noise bias · intracranial electrophysiology

Admitted 2026-11-09 17:55 UTC5 citing publications

References

usesA fixed covariance rule gave higher SEEG site accuracy than a diagonal rule in offline tests from five patient sessions sci:sha256:1407cd9ac712a4bcd551a3738cc90c3fab309b871572cbd6fc644b41555f7886
Uses archived voltage bins, source metadata, contact selection, pulse inclusion, and raw extraction code.
usesdoi:10.18112/openneuro.ds004457.v1.0.2
Analyzed voltage bins and metadata are from OpenNeuro ds004457 v1.0.2; the source package records file hashes and source URLs.
supportsdoi:10.1523/JNEUROSCI.1325-22.2023
Reports site-dependent responses in the cohort analyzed here.
doi:10.1371/journal.pcbi.1005508

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usesOne selected remote pair gave 80.8% accuracy on later pulses within site blocks for two known neighboring sites in five SEEG sessions
Its early pre-pulse noise scale and separate-group contrast informed the pair-ranking design. This test fits a separate fixed metric for each recording pair. No code or result array was copied from that publication.
usesA fixed site variance rule did not reduce mean site log loss in five offline SEEG sessions
Uses its unchanged voltage-bin arrays, event tables, fixed recording contacts, and pinned raw file manifest. The new analysis tests site variance factors with separate early, probability-fit, and later pulse groups.
usesA 90% calibration voltage map left positive test contrast outside its space in five offline SEEG sessions
Its separate-group site distance and matched before-pulse comparison supplied the score principle. We apply it to retained and residual parts of a calibration-only voltage subspace.
usesNeighboring SEEG site responses had estimated shape separation of 0.16 at 20–100 ms in five sessions under stable means and independent group errors
Its repeated site-distance result defined the scientific gap: voltage distance does not separate response size from shape. The present study did not import its fitted noise scale or result arrays.
usesNoise correction gave a mean change of +0.39% in forecast error for 20–500 ms SEEG distances in five patients
This same-cohort work used separate pulse groups for distance estimation. It informed the independent-target design and the limits of a recorded distance statistic. Its scores are not input to the new forecast analysis.