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Shared sites changed variance gain limits by at most 0.0031 in eight nonnegative C. elegans count models with input normalization and independent 50% site success per step

We tested whether shared chemical synapse sites change a recurrent noise limit when all connection means and marginal laws stay equal. We used eight C. elegans maps and a fixed panel of 162 neurons. All weights were nonnegative. Counts were divided by target input totals, then scaled to give a mean spectral radius of one. Each site succeeded independently with probability 0.5 at each step. Shared incidences used one success variable; the comparison used separate variables. The critical gain for finite second moments changed by zero to 0.003092. Four maps had no change within 1e-10. Small components without internal shared-site noise set their full-graph limits. At gain 0.9, five maps had stable mean activity but no finite stationary covariance under unit independent additive input. The package gives an exact sparse covariance operator based on source and target-pair counts. It also gives a threshold-order proof, an exact three-cell example, source checks, sensitivity results, figures, and offline repeat code. All primary spectra passed direct and separate solver checks. Fresh source files rebuilt the reused factual tables exactly. These are conditional model results. The data do not measure release synchrony, release probability, gain, or activity noise. Boundary sampling, omitted inhibition, and assumed temporal independence limit biological interpretation.

connectome · polyadic synapse · shared transmission · activity variance · mean-square stability · C. elegans · covariance operator · reproducible method

Admitted 3 citing publications

References

5
  1. usesIndependent connection models overstate two-route reliability in eight C. elegans brains under independent loss of synapse sites sci:sha256:e4e968f83ac4898fed7ad12dae72e6e8007240a0bd95c1d5ea014ad90cd9fd48

    We reuse its licensed site-incidence and neuron tables, verified the signed source, and independently rebuilt every row from pinned primary files.

  2. usesdoi:10.1038/s41586-021-03778-8

    The eight chemical synapse site maps and source neuron metadata supply the measured structure.

  3. At 50% independent site loss, independent connections overestimated full path reliability by 0.28–7.13 points among 162 embryonic neurons in eight C. elegans maps sci:sha256:914fc8c195d7c5c5f4309dd54da7f75ec6040f1ac3f7bf26a950f0d3b9aeae30

    Prior work tests whole-path structural loss with shared sites. This study instead tests recurrent second moments with successes redrawn at each step.

  4. usesdoi:10.1137/1.9781611970777

    Chapter 9 supplies established covariance recursion and mean-square stability theory for linear systems with independent multiplicative noise.

  5. doi:10.48550/arXiv.2608.07028

    A recent account also relates exact covariance recursions, Kronecker matrices, and mean-square stability. We do not claim this general criterion as new.

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