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Motor partner clustering in one dauer C. elegans map was within sampled ranges under degree and contact area constraints

We tested motor partner clustering in one dauer C. elegans map. The test used 38 motor neurons from Yim et al. (2024). An undirected partner edge required a positive chemical entry in either direction. Mean clustering was 0.401 in Dauer and 0.319 in Adult 2. Four chains per map gave model means of 0.364 and 0.327. The central 95 percent sampled ranges were 0.291 to 0.451 and 0.226 to 0.435. Both observed scores and both triangle counts were inside these ranges. The model fixed every cell degree. It also fixed total edge counts in three positive contact area groups and a zero-contact group. The two-group and common-node checks kept this result. Five-group chains had poor mixing for retained original edges. That check remained inconclusive. These model ranges are not animal population intervals. The sampler has no proof of full contact-constrained graph-space coverage. This result concerns undirected partner choice. It does not re-test the directed clustering measure or establish a physiological mechanism.

connectome · C. elegans · dauer · motor neurons · contact area · clustering · graph reference · reproducibility

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References

6
  1. usesdoi:10.1038/s41467-024-45943-3

    The released chemical and contact matrices supply the biological measurements. The prior motor-clustering result motivates this new test of an explicit undirected partner projection.

  2. usesdoi:10.5281/zenodo.10516067

    We inspected the source code and used its motor type labels at Git commit 059206c08467e9ae8085d16ebb1ff2a416e6a428. No upstream source code is bundled.

  3. usesdoi:10.1038/s41586-021-03778-8

    Yim et al. include non-dauer developmental maps from this source. We use the maps as released in the 2024 comparison.

  4. usesdoi:10.1038/s41586-019-1352-7

    The 2024 comparison includes prior L4 and adult chemical measurements. The two additional adult degree-control maps provide scope checks.

  5. supportsFeedforward triad counts without reverse edges were within contact area control ranges in seven C. elegans maps at a cutoff of one synapse sci:sha256:23bc4cffbc09ef6735c01947c2b69570c66ef530ea1470aee89e9d5782379a9e

    This earlier SCI study shows that measured contact controls and exact motif definitions can change inference in a different C. elegans panel. We extend that question to motor partner clustering in a dauer map. We do not reuse its code or extracted data.

  6. usesdoi:10.1137/16M1087175

    Fixed-degree simple labeled graph models and symmetric edge-switch sampling supply the method background.

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