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Two Hurst methods had positive mean cortical order agreement in iEEG and fMRI; fixed clinical transfer tests failed

We tested whether two Hurst methods keep cortical order within human measurements. We also tested whether regional maps transfer between measurements. Public source studies supplied separate iEEG and fMRI cohorts. Development used 33 and 18 people. Fixed raw-map tests retained 41 and 34 other people. Mean pair-order agreement was 77.8% and 62.0%. Their 95% person intervals were 72.2–83.4% and 60.1–63.8%. Both modalities passed the mean and majority tests. Holm p was 1.57e-8 for three claims. A later check used a bound on the mean. It also passed, with Holm p = 0.01519. This check was added after the results. A selected anatomical reversal failed. A later fixed test used regional references from the other modality in disjoint clinical groups. Mean transfer scores were -0.0803 in 23 iEEG patients and -0.0006 in 33 fMRI patients. Their intervals were [-0.1713,0.0106] and [-0.0878,0.0866]. The shared positive transfer rule failed. No full fMRI target set stayed supported in 999 electrical reference-person resamples. Thus no complete reference-resampled MRI interval was available. An exact shared-error example gave perfect method agreement with no latent regional order. Positive method agreement therefore does not establish a shared neural hierarchy. Sparse clinical sampling, source exclusions, short MRI records, unequal filters and cohorts limit scope. No neural cause or clinical benefit is established. The package gives a benchmark tool, seven licensed source tables, source hashes and local plans. It includes all negative scores, figures, code and repeat instructions. Independent scalar checks matched all primary scores.

Hurst exponent · intracranial EEG · fMRI · cortical hierarchy · rank agreement · cross-modal transfer · reproducibility

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References

10
  1. usesdoi:10.5281/zenodo.17677314

    All seven public processed input tables and the original estimator function come from version v1.0.0.

  2. usesAt a 5% site threshold, 9 of 28 iEEG and 18 of 19 fMRI reference people had a cortical Hurst map flag sci:sha256:a1e0476a1200a8b915459e4226c6367f721fd6f4d1df683043c59c48eccc1fad

    We reuse two licensed source table exports, source pins and the attributed source exporter; the new endpoint is raw anatomical order.

  3. usesWith fixed references, two Hurst measures shared 64% of selected cortical regions in ten iEEG patients and 32% in 34 fMRI controls sci:sha256:8320cfd48d3caeafef832c2074bb81842543379ade4014c1cc447f73d36adc77

    We reuse five licensed source exports and source estimator code. Its absolute-deviation selection test motivated a separate raw-order and cross-modal template test.

  4. usesAbsolute Hurst deviations separated treatment labels within regions in 20 iEEG patients; fMRI evidence from 10 patients was uncertain sci:sha256:bff5c89b64b8cbdd26023eff9e94248052a135c375676a87b0d3931d7ab74ab3

    The attributed source exporter originates in this work.

  5. usesdoi:10.1093/brain/awy035

    The electrical reference derivatives originate in the MNI normal-labelled iEEG atlas.

  6. doi:10.1002/hbm.25801
  7. doi:10.1109/IJCNN.2012.6252657
  8. doi:10.1109/TSP.2007.896269
  9. usesdoi:10.1093/jrsssb/qkad009

    An added post-result mean check applies established bounded-mean mixture betting to the person scores.

  10. usesdoi:10.1214/20-AOS2020

    The statistical check averages e-values and uses their reciprocal Markov probability bound.

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