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A sleep decrease in repeated lag asymmetry was not confirmed in 39 SEEG patients and 16 fMRI records

We tested whether N3 sleep reduces lag asymmetry that repeats across two time blocks. Separate human studies supplied SEEG power envelopes and regional BOLD signals. A local plan fixed the score and tests before human outcomes. Twelve SEEG patients formed discovery. Thirty-nine other patients tested the fixed rule. Sixteen fMRI records formed the second modality test. Two identity schemes used 15 or 16 fMRI units. Mean wake-minus-N3 block product was -0.000142 in SEEG, with a 95% person interval of -0.003011 to +0.003163. The fMRI mean ranged from +0.000901 to +0.001405; its interval union was -0.014972 to +0.016761. All three planned cross-modal Holm p values were 1. No shared claim passed. Descriptive ratios of mean repeated product to mean within-block energy were -2.69% and -1.68% in SEEG and about 9-10% in BOLD. These block statistics are not neural signal fractions. A positive squared lag score did not by itself show repeated direction. Reversible models had positive squared scores and near-zero block products. A delayed common driver produced a positive product without direct site interaction. The contribution is a compact human sleep benchmark and a fixed negative result, not a new general estimator or common neural mechanism. Short windows, selected clinical tissue, unequal sampling, missing fMRI nuisance traces and uncertain identities limit inference. The package preserves code, data provenance, source terms, complete results, figures and repeat instructions.

human neuroscience · SEEG · fMRI · sleep · lag asymmetry · repeatability · negative result

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References

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  11. usesDeep sleep did not confirm a shared rise in magnitude memory above a phase model in 37 SEEG patients and 16 fMRI records sci:sha256:cd92fc7b2beb272cbed4ca302841eeb7ea2dee2cbc55359cc210fd764683417a

    We adapt its MIT source access and preparation code and reuse its fixed CC BY BOLD windows. A fresh source extraction matched the windows exactly. The target score differs.

  12. usesSigned 10 ms covariance gave a mean patient error reduction of 3.56% in 19 selected SEEG records filtered at 1 to 40 Hz sci:sha256:a2fcdd0f9017eb9a4c59ed0d7602b9e8f5a0bce5d0e0055ca22efddefe681576

    Its repeated signed lag covariance result motivated this sleep-state and second-modality test.

  13. usesWake-to-N3 coupling scores passed primary tests in 34 SEEG patients and eight fMRI participants but not SEEG spectrum and gap checks sci:sha256:6a5d54674073cd1bb6cf878d9ef6543dea818b4029b02d94f4cd45d77cee2a5b

    Earlier source access and segment processing entered via the adapted code in SCI 9d1370b1.

  14. Stable tie ranks with a reversal shortcut gave false time asymmetry in symmetric SEEG controls from 36 HUP patients sci:sha256:3219131c298b3069190105f1202862b1be3ea5793eaedc815a6ac7b07979f0ef

    Prior tie-rank audit informed average ranks and explicit reversal checks.

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