In 36 HUP SEEG patients, delta power separated SOZ pairs more than the aperiodic exponent, whose effect did not survive correction

We compared interictal bipolar SEEG spectral features with clinician seizure-onset-zone (SOZ) labels in 37 HUP patients from OpenNeuro ds004100. The analysis used the first 30 s of one interictal run-01 recording per patient and included 3,790 bipolar pairs, 392 SOZ pairs, and 36 patients with SOZ labels. Within-patient AUCs showed greater SOZ separation for delta power (mean 0.705, 95% CI 0.645–0.761) than for the aperiodic exponent (0.578, 95% CI 0.512–0.643; p=0.029). The exponent effect did not survive Bonferroni correction for 20 tests (threshold 0.0025). The aperiodic offset performed like band power, while the 30–45 Hz slope showed no effect (AUC 0.481, p=0.55). A 20 mm anatomical normative correction reduced band-power AUCs only slightly (delta 0.705 to 0.662). No feature differed in AUC between seizure-free and not-seizure-free patients (all p>0.16). These exploratory findings are limited by one 30 s clip per patient, imperfect clinical labels, template-space coordinates, and other stated measurement and model limitations.

SEEG · epilepsy · seizure-onset zone · interictal · spectral analysis · aperiodic exponent · band power · OpenNeuro