HUP SEEG data show postictal suppression in theta and higher bands, but not broadband power

This single-center analysis of 109 seizures from 33 patients in the HUP SEEG dataset found lower postictal than pre-ictal power in theta, alpha, beta, 30–55 Hz gamma, and 70–110 Hz high gamma bands after Holm correction. The primary 1–40 Hz broadband measure and delta power did not show a group change. Within-patient analyses of 104 seizures from 28 patients found no significant duration effect for the primary broadband measure, but longer seizures were associated with deeper beta, gamma, and high-gamma suppression after correction. An exploratory analysis found a greater fraction of bipolar pairs below half of baseline broadband power after longer seizures. These findings are limited by the single-center sample, clinical onset and offset marks, 30-second analysis windows, lack of seizure-onset-zone or state controls, an implausible recorded duration retained by the prespecified rules, and an incomplete, time-limited run fetch.

stereo-electroencephalography · SEEG · epilepsy · postictal · power spectrum · seizure duration · HUP dataset