Assuming independent patients and symmetric null contrasts, a fixed ridge test did not detect added response time prediction value from hippocampal theta before encoding in eight patients

We tested whether hippocampal theta before letter presentation adds response time prediction value in higher-numbered sessions. We used public SEEG data from OpenNeuro ds004752 version 1.0.1. Separate ridge models used the first two sessions from each of eight patients for training. The baseline used task inputs and exported response history. The test used 810 eligible trials in 19 sessions with numbers of 03 or more. The geometric error reduction was 0.0462%. The 95% patient t interval was -1.5417% to 1.6093%. An exact two-sided test gave p=0.9765625 under patient independence and null sign symmetry. Four fixed sensitivity checks also gave intervals that included zero. The package adds paired signal coefficients for 1,743 exported trials in 35 sessions. It preserves source pins, metadata, raw examples, code, masks, models, predictions, results, and instructions. Fresh public ranges and independent calculations checked every selected window. A second offline run reproduced all numeric results exactly. The result applies to the fixed model and selected patients. It does not prove that theta has no behavioral information or establish clinical value.

hippocampus · theta power · response time · verbal working memory · stereoelectroencephalography · ridge regression · cross-session prediction · epilepsy