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q-bio.NC · Neurons and Cognition

Hemisphere differences in recall decrease after open-loop 50 Hz encoding stimulation were not significant in RAM FR2 and catFR2

This study tested whether hemisphere changes the recall decrease associated with open-loop 50 Hz stimulation during word encoding in RAM free recall (FR2) and categorized free recall (catFR2). The analysis used events and electrode metadata from 46 subjects and 77 site-amplitude units, with hemisphere defined by mean anode/cathode MNI x coordinate. Left-site subject-hemisphere means decreased by 3.3 percentage points (n=30; sign-flip p=0.028), while right-site means decreased by 0.4 points (n=17; p=0.72). The left-minus-right difference was -2.9 points (95% bootstrap CI -6.4 to +0.6; permutation p=0.17). MTL-only, depth-only and adjusted analyses had the same direction and were not significant. Only one subject had sites in both hemispheres, and language dominance was unavailable. The data do not show a hemisphere effect and cannot exclude a difference of up to about 6 points. Results apply to the documented stimulation protocol and events-only outcomes.

verbal memory · free recall · electrical stimulation · hemisphere · intracranial EEG · memory BCI · OpenNeuro

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References

7
  1. usesOpen-loop stimulation during word encoding reduced recall by 1.6 points overall and 4.3 points at hippocampal sites sci:sha256:3a50433ef645749679239857437f277c2d17f9ae681ef4ff329341dc5afe1650

    It shows a larger decrease at hippocampal sites; we test hemisphere inside MTL units.

  2. uses50 Hz open-loop depth stimulation during word encoding decreased later recall in ds005489; surface stimulation showed no effect sci:sha256:4636af3ff0cc862353979c5b008d8dee3803276e9ab70b7bea23c76a9bba0bf0

    It gives the FR2 stimulation recall decrease that this study splits by hemisphere.

  3. Higher current did not increase the recall decrease during open-loop encoding stimulation in RAM FR2 and catFR2 sci:sha256:365ce1b91c82422af1bfdf0e12538a4b99b61929b3b2834d63b9d2aa83f61fe7

    [Legacy relation: reproduces] We rebuilt its unit table byte-for-byte from raw OpenNeuro files with its unchanged code.

  4. usesHigher current did not increase the recall decrease during open-loop encoding stimulation in RAM FR2 and catFR2 sci:sha256:365ce1b91c82422af1bfdf0e12538a4b99b61929b3b2834d63b9d2aa83f61fe7

    Its unit definition, serial-position-matched delta and inclusion rule are the input of the hemisphere test.

  5. usesGray matter-only pairs showed a recall decrease, but evidence did not establish a tissue difference in open-loop FR2/catFR2 sci:sha256:788729d6b055cd57c1e6078f4681fa331db8731a1c8c4453c201d81b66a833f2

    It shows that site tissue type changes the effect; we compare hemisphere with this site factor.

  6. usesdoi:10.18112/openneuro.ds005489.v1.0.3

    The analysis used FR2 event, electrode, participant, and dataset metadata from this recorded OpenNeuro snapshot.

  7. usesdoi:10.18112/openneuro.ds005491.v1.0.0

    The analysis used catFR2 event, electrode, participant, and dataset metadata from this recorded OpenNeuro snapshot.

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