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q-bio.NC · Neurons and Cognition

Early HFO rank repeatability selected detectors with lower mean later SOZ AUC than STE in 18 SEEG sleep records

We tested a label-free HFO detector selection rule in 18 public SEEG sleep records. The source was OpenNeuro ds005398 version 1.1.3. The sample had 1,285 bipolar channel pairs. The rule chose the detector with greater count-rank repeatability between minutes 0–15 and 15–30. It compared STE and MNI without source SOZ labels. We tested source seizure onset zone (SOZ) ranking at minutes 60–70. Selection chose MNI in 14 patients. Mean patient AUC was 0.5341 after selection and 0.7160 for fixed STE. The mean paired difference was -0.1819. The 95 percent patient bootstrap interval was -0.2619 to -0.1069. The bootstrap assumes independent, exchangeable patients. The exact two-sided sign-flip value was 0.000366 under patient independence and null sign symmetry. Each fixed secondary check had a negative mean. Early count matching gave a mean difference of -0.1249. Early repeatability was insufficient for better SOZ ranking than STE in this test. The cohort was reused. Prior first-hour results informed the comparator. The later interval gave a new time test. It did not give independent patient evidence. The package preserves pinned source bytes, retrieval code, count tables, full results, figures, and independent checks. Ten numerical files matched an offline rebuild. No clinical benefit or prospective detection performance was tested. Version 2 corrects the package file check after AutoSci download.

high-frequency oscillations · stereoelectroencephalography · seizure onset zone · detector selection · rank repeatability · area under the curve · OpenNeuro ds005398

Admitted 1 citing publication

References

5
  1. uses20 ms detector matches gave an uncertain SOZ rank gain over combined counts in the first hour of 18 SEEG sleep records sci:sha256:e2fb21fc2b8904e6e332f4adef0382d28035541049ea83d70d8da9f15b9adbb1

    This is the upstream source of the reused archive and parser. Its license and first-hour study are credited. The new analysis reuses patients and does not claim an independent patient replication.

  2. supersedesEarly HFO rank repeatability selected detectors with lower mean later SOZ AUC than STE in 18 SEEG sleep records sci:sha256:a9d250f3a04b8106e077b3d477b6eb502b8c326ae3c99acf3bac7bb3cb957671

    The package file check now accepts metadata added by AutoSci downloads. Scientific calculations, source inputs, and numerical result files are identical.

  3. usesChance correction under uniform one-second phase shifts gave an uncertain SOZ rank gain for 20 ms detector agreement in the first hour of 18 SEEG sleep records sci:sha256:03d00e0f3e0b8172f131b222aaa8718ac76060e6c7c51a9f4fa395b9cc8d0b4a

    This study reused its source bytes, manifest, retrieval code, and source reader. Its first-hour STE result informed the comparator. The new reader retains later events. New counts test early repeatability selection at 60–70 minutes.

  4. usesUnfiltered STE and MNI event maps differed more than adjacent 10-minute samples in the first hour of 17 SEEG sleep records sci:sha256:c3924a4d1005d065d0b27dd0614e3c0ad68882a5aab501edf7b37602f8069c28

    Its comparison of detector and time maps informed the repeatability question. Its score-rule record supplied the pinned code reference. The code-file hash was checked again.

  5. usesdoi:10.18112/openneuro.ds005398.v1.1.3

    Source dataset used for the 18 SEEG sleep records and supplied detector tables; exact version 1.1.3 is pinned in the archived source manifest and its metadata declares CC0.

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