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Age gave no delay prediction gain in selected Allen mouse visual cortex connections

We tested whether recorded age improves predictions of local synaptic onset delay after distance and cell labels are known. We used linked cell-pair geometry and physiology in the Allen Synaptic Physiology r2.1 small database. We held out whole inferred animals in five repeated five-fold tests. The primary models also used sex and calendar date. Adding linear age gave an MSE gain of -0.003676 ms squared in 902 excitatory connections and -0.000465 ms squared in 1327 inhibitory connections. Neither group gave a clear gain. Excitatory error rose slightly under conditional donor intervals. These intervals hold fitted models fixed. The data cover a narrow age range, mainly near postnatal day 45. This result does not show that maturation has no effect on delay. We supply selected records, code, predictions, an evidence check, and data provenance.

Allen Institute · synaptic delay · age · cell-body distance · held-out animals · mouse visual cortex

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References

6
  1. usesdoi:10.1126/science.abj5861
  2. useshttps://allen-synphys.s3-us-west-2.amazonaws.com/synphys_r2.1_small.sqlite
  3. doi:10.1523/JNEUROSCI.2979-10.2010
  4. doi:10.1038/s41467-020-18984-7
  5. usesCell-body distance improved delay predictions after PSP rise time in 1,136 Allen mouse inhibitory connections sci:sha256:dfa43b491da53ece8d1276e8b40aee38fc9b1f154e8fdeccae0ea2e75e403d8d

    This published result motivates a test of added age information after distance and cell-label controls.

  6. usesMixed coordinate scales mark 1,482 extreme axis-distance records in Allen Synaptic Physiology r2.1 sci:sha256:d273d0734b7c3235867e51fafe39bf8c726b33aee890c2c5859ad34c9be9b686

    This published audit informs the choice to avoid cortical axis distances.

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