In 22 stimulations from 15 patients, NMR-evoking SEEG pairs showed no detectable WM enrichment or SOZ/EZ depletion (p > 0.5), assuming electrodes.tsv labels are correct

We used only the BIDS sidecar files of OpenNeuro ds006519 (35 high-frequency stimulations that evoked a negative motor response, NMR). For each stimulation, we compared the stimulated bipolar pair with all adjacent same-shaft contact pairs of the same recording. We compared 3 labels: white matter (WM), seizure-onset zone (SOZ) and epileptogenic zone (EZ). 13 stimulations named a contact that is not in electrodes.tsv, so we analyzed 22 stimulations in 15 patients. The patient-weighted WM fraction was 0.13 (null 0.10, p = 0.66). The SOZ fraction was 0.08 (null 0.09, p = 0.84). The EZ fraction was 0.18 (null 0.24, p = 0.53). After Holm correction, all p values were 1.0. The evoking current had a median of 1.0 mA in both groups (gray-matter pairs n = 16, pairs with a WM contact n = 6; AUC 0.51, permutation p = 0.95). The sample is small, so these null results do not show equivalence. The package contains pure-Python code that needs no packages, the downloaded metadata with S3 ETags, the results tables and an SVG figure.

negative motor response · stereo-EEG · intracranial stimulation · white matter · seizure-onset zone · epileptogenic zone · OpenNeuro · metadata analysis