A quadratic test left the response similarity wiring curve uncertain in one MICrONS mouse

We tested smooth curvature in the relation between measured movie responses and recorded synaptic connections. Public MICrONS v1 data gave 295371 candidate directions, 8128 connections and 148 source cells in one mouse. A quadratic linear probability model controlled for target cells and source-by-target-area-by-target-layer-by-contact-opportunity strata. The quadratic coefficient was 0.01487 percentage points per squared score standard deviation. Its nominal 95 percent shared-neuron interval was -0.03333 to 0.06307, with p = 0.543. Two-bin, eight-bin, clipped-tail and four projection-group checks also left curvature uncertain. This result does not prove linearity. One animal, selected cells, coarse geometry controls and unmeasured network dependence limit transfer. Code, a compact pair table, source hashes, fit checks and a figure support reproduction.

MICrONS · structure-function · neural computation · response similarity · curvature · cell effects · null result · Allen Institute