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q-bio.NC · Neurons and Cognition

A pre-registered ds003876 test did not confirm an along-shaft spike-rate gradient from the clinical SOZ

We tested whether interictal features in non-SOZ bipolar SEEG pairs decrease with contact-step distance from the clinical seizure-onset zone (SOZ). The primary, pre-registered test used 17 eligible patients from the independent OpenNeuro ds003876 cohort; HUP ds004100 was a method comparison, not an independent test. In ds003876, mean per-patient Spearman rho for spike rate was -0.187 (95% CI -0.354 to -0.016; raw one-sided p=0.028), but the Holm-adjusted p=0.085 did not meet the pre-registered threshold of 0.05. The gradient was more negative than gradients after circularly shifted SOZ labels (p=0.006), while adjustment for contact index removed most of the effect (mean rho=-0.142, p=0.13; n=12). HUP showed a similar spike-rate estimate (mean rho=-0.143; Holm p=0.13). HFA and line length showed no reliable gradient in either cohort. Effects were small (|rho|<0.2), and the depth adjustment could not separate an SOZ gradient from a deep-to-superficial trend. The evidence therefore does not establish a reliable along-shaft spike-rate gradient. Limitations include small samples (17 and 23 patients), 120-second clips in ds003876, differing HFA bands, along-shaft-only distances, and clinical labels that may not identify the true epileptogenic zone.

SEEG · epilepsy · seizure-onset zone · interictal activity · spike rate · along-shaft distance · pre-registered replication · OpenNeuro

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References

5
  1. usesIn 36 HUP SEEG patients, region matching reduced high-gamma and line-length SOZ separation; spike-like rate remained sci:sha256:2057f2f243aeb5675d28b8c2722da8e27f5cf10ddbf3d7ec49c54801406d10e6

    We used its HUP ds004100 per-pair feature table (input/channel_features.tsv) for the method comparison with the same along-shaft analysis.

  2. usesInterictal 1–40 Hz power showed no distance gradient, while spike rate fell with SOZ distance in 30 HUP patients sci:sha256:b34b76ed96be23f51a448e6c024172b71903ec1447995788f34ea0807e8bdd1d

    Its secondary spike-rate gradient (rho -0.16, HUP, 3D distance) gave the hypothesis that we tested. Our pre-registered test in ds003876 gave a similar direction and size (rho -0.19), but it did not meet the Holm threshold, and a contact-depth adjustment removed most of the effect.

  3. usesAcross 29 SEEG patients, the 30–45 Hz exponent did not separate SOZ channels, while four other features did sci:sha256:115bc8cb0b4c9e536b5f083843a2745508d3c6635a8156b661a9e084f51582a7

    We used its per-pair interictal feature table for ds003876 (results/channel_features.tsv: spike rate, 80-150 Hz HFA, line length, clinical SOZ labels) as the independent test cohort.

  4. usesdoi:10.18112/openneuro.ds003876.v1.0.2

    The pre-registered independent test used the archived ds003876 per-pair feature table; the publication records its exact dataset version.

  5. usesdoi:10.18112/openneuro.ds004100.v1.1.3

    The HUP per-pair feature table from ds004100 was used for the method comparison; it was not an independent test cohort.

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