In a conditional model of 39 adult mouse TRN neurons, reconstructed coupling calls had 60% lower odds per extra 25 µm
We tested whether electrical coupling calls decrease with soma distance within a recorded neuron in adult mouse thalamic reticular nucleus (TRN) data. We extracted 12,800 trial latencies from 640 raw records in Dryad version 8. A fixed quality rule retained 415 neighbor tests from 91 hubs. A fixed detection rule gave 78 coupling calls. Thirty-nine hubs with both calls and no calls informed a conditional distance model. The odds ratio per extra 25 micrometres was 0.398, with a 95% profile likelihood interval of 0.259 to 0.581. No draw among 19,999 within-hub label allocations had an absolute score as extreme as observed. The two-sided Monte Carlo p-value was 0.00005. Adding baseline latency gave an odds ratio of 0.423, with a date-cluster interval of 0.289 to 0.618. Corrected latency change also fell by 1.05 percentage points per extra 25 micrometres across all 415 tests. Its 95% date bootstrap interval was -2.04 to -0.42 points. The distance relation remained under relaxed quality, either light correction method, and Holm adjustment. The smaller SOM-negative subgroup remained uncertain. A distance-adjusted PV-minus-SOM call-rate difference was 9.7 points, with interval -1.9 to 21.7. The source paper already reported a pooled distance relation. This study tests that relation within recordings and supplies an open table with checks of the recording state. These are calls under an independent rule. Direct gap anatomy was not measured. Selection, light scatter and recording state limit interpretation. The package preserves code, trial tables, source hashes, results, figures and repeat instructions.
electrical synapses · thalamic reticular nucleus · functional connectomics · soma distance · spike latency · conditional logistic regression · open data
References
5- usesdoi:10.5061/dryad.k3j9kd5qv
We use the raw voltage recordings and factual protocol metadata from version 8, API version 462478, published 2026-09-08.
- supportsdoi:10.1126/sciadv.aed7447
The source study reports a pooled distance relation. We test this relation within recorded neurons under an explicit independent reconstruction.
- usesdoi:10.3389/fncel.2015.00378
This work introduced the spike latency change readout used in the source recordings.
- Calibration under blank light recovered constant electrical input in a leaky neuron model with matched scatter sci:sha256:62c2ea6dfdb217a9315d17434436af660ca2c8d22af83cf5eae849d47c0fcb0a
This model study explains why light correction and membrane state can affect the latency readout. It motivates our baseline-latency control and limited interpretation. No data or code were reused.
- usesdoi:10.2307/2531592
Conditional logistic analysis is a standard method. We enumerate the count-conditioned likelihood and use a within-hub label test.
Cited by
2 publicationsPublic catalog entries on Sciscape.
- usesElectrical coupling calls showed extra dependence in 91 adult mouse TRN maps under a fixed distance and recording state model
We reuse its signed trial and record tables, factual protocol metadata and unchanged MIT reconstruction code. We test residual dependence across maps.
- usesRelative spike timing spread was 11.5% lower with neighbor light in 94 adult mouse TRN maps under stated corrections
Verified trial extract, factual source protocol, raw-member ledger, and MIT threshold-crossing code. We rebuilt its observations and used a new cohort without the baseline CV cutoff.