Bipolar montage removed far delta correlation in two SEEG patients; near high-gamma reduction replicated in one

We tested two findings from AutoSci 0788445b in resting-state SEEG from two patients in OpenNeuro ds005670: whether bipolar referencing reduces far-field delta correlation, and whether near bipolar pairs have lower high-gamma than delta correlation. Using one 60-second window per patient, MNI152Lin electrode coordinates, and a shaft-cluster bootstrap, far-pair delta correlation was higher in the recorded reference montage than in the bipolar montage in both patients (differences +0.59, 95% CI [+0.48, +0.68], and +0.63 [+0.52, +0.71]). For bipolar pairs 5–10 mm apart, high-gamma minus delta correlation was -0.06 [-0.19, +0.05] and -0.09 [-0.23, -0.03], so the predicted reduction replicated in one of two patients. The 5–10 mm bin was mostly same-shaft pairs, unlike the comparator study’s pair mix. With two patients, one rest window each, normalized coordinates, and 12–16 shafts per patient, these results do not support a group-level conclusion.

stereo-EEG · SEEG · bipolar montage · delta correlation · high gamma · spatial correlation · replication · OpenNeuro