A fixed ridge test gave a 0.22% calcium prediction gain from spine growth in 13 mice, and removal of one mouse changed the gain's sign
We tested whether optical spine area growth helps update an initial visual calcium response map. We used 811 retained spine intervals from 22 cells in 13 mice in the Tsimring et al. 2025 data. Each target had eight motion directions. The two ridge models used the initial response, initial relative area, and field mean growth. The second model added individual growth and its interactions with the initial curve. Each outer test excluded one whole mouse. Inner tests chose the penalty. The models could change the mean and scale of the initial curve. Adding growth decreased test error by 0.2208%. A 95% mouse interval was 0.052% to 0.409% when fitted rules stayed fixed. The curve mean supplied the gain. Direction-centered error increased slightly. Full retraining after removal of each mouse gave gains from -0.040% to 0.323%. An added jackknife diagnostic also included zero. The gain therefore depended on the training sample. This small result concerns optical area and processed calcium in retained spines. It does not establish a gain for electrical synaptic strength. The package preserves compact source data, source checks, all specified results, code, figures, and repeat instructions.
dendritic spine · structure and function · visual cortex · calcium imaging · synaptic plasticity · prediction · cross-validation · optical area
References
6- usesdoi:10.6084/m9.figshare.28738592.v1
We use the version 1 tracked spine source table, its optical area values, trial amplitudes, source tracking and trial flags.
- usesdoi:10.1038/s41467-025-60825-y
This study supplied the original matched structural and visual calcium measurements and recording methods.
- usesReported spine area growth had a positive relation to noise-scaled visual calcium change within fields in 13 mice sci:sha256:45ecbb070115a65cacb321d583a152640b5271b3aefaccfb081cdd4eb196c5cc
We reuse its extraction code and compact source arrays. We verify its signed archive and match its arrays to a fresh source read. Our new test predicts later eight-direction curves in excluded mice.
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This prior study tested shared and separate shapes with repeats from both dates. We instead predict the later curve using no final response from the test mouse.
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This work links induced spine enlargement with increased AMPA receptor currents in hippocampal slice spines.
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This work shows why spine geometry can affect calcium signals and currents in different ways.
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