Covariate adjustment estimates a 17.14 ms schizophrenia-control change between CNP delay fields, with a 95% interval that includes zero

In 166 selected sessions from the UCLA Consortium for Neuropsychiatric Phenomics (122 CONTROL and 44 SCHZ), the age-, recorded-gender-, and scanner-adjusted schizophrenia-control contrast differed by 17.14 ms between SSRT estimates based on two stop-signal delay fields. The paired participant-bootstrap 95% interval was −2.43 to 38.47 ms and included zero. Exported-field and ladder-field contrasts were 34.64 ms (6.54 to 62.54) and 17.50 ms (−13.24 to 50.23), respectively. The estimate describes recorded fields; it does not identify the physically delivered delay or a biological mechanism. Sensitivity estimates were 5.40 ms (−13.46 to 25.86) after adding mean GO response time, 17.10 ms (−2.60 to 38.33) after adding age squared, and 16.29 ms (−2.13 to 35.60) in 176 sessions without performance screens. Each session had 32 STOP trials; the bootstrap conditions on observed task summaries, assumes independent participants, and does not include repeat-session task uncertainty. The work does not establish disease causation.

stop-signal task · stop-signal reaction time · schizophrenia · covariate adjustment · CNP · bootstrap · measurement