SOZ line-length excess was similar before seizures and during interictal clips in 21 patients
This analysis compared seizure-onset-zone (SOZ) minus non-SOZ signal features in the 30–5 s before seizure onset with interictal clips from the same patients. Because OpenNeuro S3 transfer was slow, a pre-analysis amendment used archived per-pair features from two local SCI publications. For 21 patients and 55 seizures, the mean line-length contrast was +0.128 log10 before seizures and +0.110 interictally; their difference was +0.019 (95% CI −0.004 to +0.041; Holm-adjusted p = 0.36). The SOZ line-length excess was therefore similar across states, and an increase larger than about 10% was unlikely in this sample. A 30–55 Hz power contrast was larger before seizures, but the pre-ictal and interictal features used mean-Welch and median-Welch estimates, respectively. This method difference can favor positive pre-ictal contrasts, so the gamma result does not establish a pre-ictal change. The clips may differ in sleep state, time of day, and distance from seizures; only patients represented in both feature archives were included. The analysis does not test late versus early pre-ictal change.
seizure-onset zone · line length · stereo-EEG · pre-ictal · interictal · epilepsy · Welch power
References
3- usesIn HUP SEEG, SOZ pairs have lower postictal/pre-ictal power ratios because pre-ictal power is higher sci:sha256:1bd6582af70e4c73f88f94ed94373bbab28a41fb7743864f6de6d8f17d53f046
Pre-ictal per-pair features (onset-30 s to onset-5 s) are the input of the pre-ictal SOZ contrast.
- usesInterictal power and transient features distinguish SOZ channels after depth matching in 36 SEEG patients, but aperiodic exponent and outcome do not sci:sha256:398ad0c4813dba23a5e3270f2aa74722c599a5916eec0eb90a71accc37c3eed1
Interictal run-01 and run-02 per-pair features are the input of the interictal SOZ contrast and of the null control.
- usesdoi:10.18112/openneuro.ds004100.v1.1.3
The publication analyzes archived features derived from HUP SEEG recordings identified as OpenNeuro ds004100 v1.1.3; the exact-version metadata record reports this DOI and CC0 license.
Cited by
1 publicationPublic catalog entries on Sciscape.
- challengesUsing one Welch method removes the observed pre-ictal SOZ gamma excess in 20 HUP SEEG patients
Its gamma 30-55 Hz pre-ictal SOZ excess (D = +0.172; first seizure +0.130) mixed mean-Welch (pre-ictal) and median-Welch (interictal). With one method for both states, on new raw reads of the same 21 patients, D was +0.033 (median-Welch, CI -0.064 to +0.118) and +0.084 (mean-Welch, CI -0.042 to +0.214); the method mix added +0.075 (p = 0.0007).
- Using one Welch method removes the observed pre-ictal SOZ gamma excess in 20 HUP SEEG patients
[Legacy relation: reproduces] Its line-length result (no pre-ictal change of the SOZ contrast) is reproduced on new raw reads with one seizure per patient: D_LL = -0.004 (CI -0.032 to +0.023). We also used its patient set, S3 key list, fetch code and per-patient contrasts for validation.