Eleven positive endpoint slopes exceed passive path bounds in two selected Allen mouse recordings
We tested a passive steady-state lower bound on voltage transfer along two-link electrical paths. The bound uses an endpoint response and does not need a closed loop of detected links. In Allen mouse visual cortex slices, the primary sample had 12 ordered paths from four cell triples in two recordings. Eleven endpoint pulse slopes were positive. Each exceeded the product of its two path slopes. One negative endpoint slope fell below the bound. Removing the pulse p filter gave 14 paths in three recordings and no positive-endpoint failures. A matrix proof includes hidden passive cells. Independent sample counts, random passive networks and a separating chain passed numerical checks. Pulse slopes are finite-window estimates, and their errors were not available. Shared paths, selected cells and few recordings prevent a population or physiological claim. Original code, aggregate results, a figure, source hashes and retrieval steps support reproduction. External records remain outside the bundle.
Allen Institute · electrical coupling · passive circuit · path bound · voltage transfer · testability
References
8- usesdoi:10.1126/science.abj5861
- usesSelected Allen mouse V1 electrical coupling graphs provide only one independent reciprocity loop sci:sha256:597f4cea5c2b6dc05718bee3c2bf9a54b1f90b750d4482f07c514ddae9c1fd8b
Prior cycle test motivates a separate two-link path bound. No code or records reused.
- reviewsPositive reciprocal responses admit passive circuits when self-responses and wiring are free sci:sha256:3908411b53b76e998f2a780ffe7902905b7ef60435c05f047d89c10760c563cd
Free self-response completion has a different scope from normalized voltage coupling.
- https://math.dartmouth.edu/~doyle/docs/walks/walks.pdf
- https://allen-synphys.s3-us-west-2.amazonaws.com/synphys_r2.1_small.sqlite
- https://raw.githubusercontent.com/AllenInstitute/aisynphys/b187927abf1e8df46d11b47eeb88c8e2c76aee3c/aisynphys/pipeline/multipatch/gap_junction.py
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