A three-subject session-0 ds004789 SEEG pilot found no significant hippocampal subsequent memory effect
This pilot packages a Python and NumPy pipeline that reads hippocampal bipolar-channel byte ranges from session-0 EDF files at the OpenNeuro ds004789 S3 path and estimates the subsequent memory effect during word encoding. Four participants were processed before the time budget ended; after quality control, three participants with four bipolar pairs contributed results. None of five frequency bands showed a significant effect after Holm correction (all adjusted p = 1.0). The smallest possible two-sided sign-flip p-value with three participants is 0.25, so these data cannot support or reject the planned hypotheses and serve only as a pipeline test. A known defect applies the 1 mV amplitude rule before removing each epoch mean, causing DC offsets to reject most pairs. Only session 0 was analyzed. The exact dataset release was not recorded; source URLs and SHA-256 hashes are preserved in the archived results. The code and detailed results are included.
subsequent memory effect · SEEG · hippocampus · free recall · range requests · pilot study
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4 publicationsPublic catalog entries on Sciscape.
- challengesHippocampal theta power was lower for recalled words in 16 SEEG patients
Same question and dataset. The 3-subject pilot could not make an inference and its theta means were positive. With 16 subjects and an amplitude rule that keeps almost all words, hippocampal 2-8 Hz power was significantly lower for recalled words.
- usesHippocampal encoding power did not predict later recall in seven SEEG patients, but moderate effects remain possible
We reused and corrected the pilot range-request pipeline (QC defect fixed) and extended it with a theta 3-8 Hz band and a tilt score.
- supportsNo significant spectral-tilt subsequent memory effect was detected in 21 pure-SEEG patients
That 3-patient pilot found no hippocampal subsequent memory effect in ds004789. Our 15-subject hippocampal analysis and 21-subject all-pair analysis also find no significant effect after control for list-level confounds.
- usesHippocampal SEEG power did not distinguish later-recalled from forgotten words in a 14-patient free-recall sample
I used the pre-specified plan, hippocampal label rule, Morlet/Welch-t analysis code and group-test design of this 3-subject pilot. I fixed its QC defect (mean removal before the 1 mV rule), added parallel screening of all participants, and extended the sample to 14 subjects.