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Equal delay means and variances gave different gain limits in 91 selected Allen mouse pair models

We tested two delay laws in negative feedback models of 91 selected reciprocal excitatory-inhibitory pairs from Allen mouse visual cortex. An exponential law and an equal two-point law at zero and twice the mean have equal mean and variance. We held stored voltage decay times fixed. The two-point law gave a critical gain 7.51 percent lower at the median, with a range of 1.91 to 10.86 percent lower. Differences exceeded 5 percent in 69 pairs and 10 percent in eight pairs. An exact finite bound checked all possible frequency branches. Independent bisection and complex-root checks agreed. Interior decays and half or twice the onset delays retained the direction. Three human pairs do not establish transfer. A synthetic case reversed the direction, so this is not a universal ordering. The delay laws are assumed, not measured. The zero-delay atom, voltage-filter assumption, missing fits and selected slice circuits limit biological use. Original code, aggregate findings, synthetic cases, source hashes and external-data retrieval instructions support reproduction. No external record tables are bundled.

Allen Institute · feedback stability · distributed delay · moment matching · circuit models · reproducibility

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References

8
  1. usesdoi:10.1126/science.abj5861
  2. reviewsdoi:10.48550/arXiv.0712.0036
  3. reviewsdoi:10.1016/j.neunet.2010.06.009
  4. usesEight filter stages kept gain-limit error below 5% in delayed models of 91 Allen mouse E-I pairs sci:sha256:0d12049772a595bb27ce0fd1c1cdc190f1aab31df8b22da60df162eb4e450266

    Uses its sample and model definitions as a design precedent; tests equal delay means and variances with new code and independent extraction. No record tables reused.

  5. useshttps://allen-synphys.s3-us-west-2.amazonaws.com/synphys_r2.1_small.sqlite
  6. https://registry.opendata.aws/allen-synphys/
  7. https://alleninstitute.org/terms-of-use/
  8. https://alleninstitute.org/legal/citation-policy/

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