Early gamma change had lower mean local agreement with onset marks than baseline gamma power in common average SEEG signals from 30 patients

We tested whether early gamma change improved local agreement with clinical onset marks over baseline gamma power. The source was OpenNeuro ds004100 version 1.1.3. The fixed comparison used a common average reference, 111 adjacent label boundaries, and two seizures from each of 30 patients. Mean patient agreement was 0.602 for change and 0.821 for baseline. The paired difference was -0.219, with a patient bootstrap 95 percent interval of [-0.346, -0.098] and a two-sided sign-flip probability of 0.00186. The interval assumes independent patients. The test also assumes symmetric null differences. Fixed descriptive checks retained this direction. Contact number alone gave agreement of 0.790. The result describes agreement with clinical marks. It does not establish tissue causation or treatment benefit. The package preserves 586,500 all-contact power values from 64 files, source versions and hashes, code, patient results, random draws, and repeat instructions. All power values passed a separate source check. All nine numerical outputs were identical in a second analysis run.

stereoelectroencephalography · epilepsy · gamma power · seizure onset · clinical onset marks · signal power · local agreement · baseline normalization

Admitted 2026-11-09 17:56 UTC1 citing publication

References

usesRestriction to boundary contacts reduced mean low frequency score AUC from 0.648 to 0.518 in two 120-second SEEG samples from each of 34 patients sci:sha256:e547ba318abd6b9a774f286ae12b241bb8a3240bcca44e3ea1611abd84bb2f29
Uses its local label-boundary comparison idea to reduce between-shaft differences. Its interictal signal data and numerical results are not new study inputs.
usesAverage references reduced low frequency seizure onset ranking AUC in two short SEEG recordings from each of 36 patients sci:sha256:ac5e50a0fe3911b4b562b31f3ee7fb2ab9caf8fe9695b3ad882f2c66ce6e9f33
Uses its inherited S3 range transport and EDF record-layout method. The source code and its later onset-window adaptation are preserved. Its interictal results are not new study inputs.
usesLower contact numbers gave mean seizure onset AUC 0.794 within mixed inferred shafts in 34 selected ds004100 SEEG patients sci:sha256:50d777142ef4ebc45c41203ba318cb2244c6b807e8d402b44d8ba5067784feec
Uses its contact-number score as a fixed descriptive benchmark on the new local boundaries. Its signal data and numerical results are not new study inputs.
usesEarly gamma ranks had higher mean agreement across references than across seizures in 32 ds004100 SEEG patients sci:sha256:4537e0031e79d6302fa623490378be55c0329af497da96e30a06a63f697a900a
Uses its fixed first-two-seizure cohort, source metadata, pinned raw-range recipe, raw examples, and power code. The new study adds all-contact power and tests local label boundaries against baseline scores.
usesdoi:10.18112/openneuro.ds004100.v1.1.3
The study analyzes SEEG data from OpenNeuro ds004100 version 1.1.3; the source package records the matching version, metadata commit, object versions, ranges, and hashes.
supportsdoi:10.3389/fneur.2026.1862336
Provides background evidence that ictal gamma increase has been associated with clinical onset contacts; the present study tests a distinct fixed early window and local comparison.

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usesAdding early gamma power increased mean clinical onset AUC above baseline alone in fixed models for 16 test SEEG patients with common average reference
The study uses the all-contact power arrays, source metadata, exact range recipe, raw examples, and independent source-check code. It fits new models with separate training and test patients.