Clusters of the six largest high frequency power windows showed no clear label difference in 19 ds003876 SEEG patients. Tests assumed independent symmetric patient contrasts.
We repeated a test of large power window clusters in an external SEEG cohort. We used 19 patients from OpenNeuro ds003876, version 1.0.2. We selected the six largest one-second powers in the 80–150 Hz band, with 118–122 Hz excluded. The cluster score counted selected neighbors. The local comparison used 77 marked and 254 unmarked pairs in 45 contact name groups. Unmarked contacts had source value n/a. Groups, clips, and patients had equal weight at each level. The mean marked minus unmarked difference was +0.59 percentage points. The conditional 95 percent patient interval was −3.38 to +4.97 points. The exact two-sided test gave p = 0.795 under independent symmetric patient contrasts. The local AUC was 0.486. A descriptive three-window check gave a negative difference of −2.80 points, with interval −5.27 to −0.16 points. Fresh pinned source ranges reproduced all 408,240 power values exactly. Separate calculations and a full offline repeat matched the results. The package preserves code, inputs, metadata, source recipes, results, and instructions. The primary result does not establish equal scores or clinical benefit.
stereoelectroencephalography · seizure onset zone · high frequency power · time clustering · patient-level inference · OpenNeuro
References
5- usesResidual 80 to 150 Hz concentration gave an uncertain mean AUC gain of 0.021 in 19 NIH and JHU SEEG patients after HUP fitting sci:sha256:23858f32ccd5c2bb68e5b977c6ed5cf2634319cf7f1b9de18608070e6e2cd68c
Uses the 19-patient external window powers, raw fixture, source metadata, selection rules, pinned range recipes, and source helper code. All imported hashes were checked. All powers were rebuilt from fresh pinned public source ranges.
- Time clustering of the six largest 80–150 Hz power windows gave a mean local seizure onset difference of −0.48 percentage points. Tests used two 60-second clips per patient in 30 SEEG patients. sci:sha256:d3e27309aae679250f81d96def4ca8f87c4dbc3c31a1b24875054ab506e3feee
[Legacy relation: reproduces] Repeats the fixed six-of-60 high frequency window adjacency score and local equal-patient label contrast in an external 19-patient cohort. Preserves the original plan, score code, proof, and HUP summary. Uses an exact test in place of the original random sign-flip test.
- usesdoi:10.18112/openneuro.ds003876.v1.0.2
The analyzed external SEEG records are from OpenNeuro ds003876 version 1.0.2; the saved source metadata and pinned range receipts identify the records.
- doi:10.1038/s41593-021-00901-w
- doi:10.1101/2021.10.15.464594
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