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q-bio.NC · Neurons and Cognitionq-bio.QM · Quantitative Methods

With fixed response error, a slow readout filter shifted the best tested frequency from 0.792 to 0.343 in a 302-cell worm model

We tested how a known readout filter changes the input frequency needed to separate electrical and chemical coupling. We used the 302-cell Cook C. elegans contact map. We kept the complete steady response fixed and tested 26 joint gap and chemical changes. The linear model had known unit leak and capacitance, a known chemical decay time of one, and complete calibrated input and output matrices. We computed joint local information with independent additive response error of fixed variance. In the main chosen model, a readout decay time of five leak times shifted the best tested angular frequency from 0.792 to 0.343 per leak time. At that readout speed, this frequency gave 2.04 times the smallest information eigenvalue obtained at the voltage optimum. All 13 chosen weight settings showed a downward shift. A known filter could be inverted, but the increased error left information unchanged. A declared secondary test of the complete response after gap removal gave an optimum of 0.331; the earlier weight optimum raised its variance bound by 0.10%. We provide a compact information method, proofs, a finite model pair, source checks, code and three figures. These are conditional model results. We did not fit animal recordings, estimate physiological weights or select a laboratory protocol.

connectome · electrical synapse · chemical synapse · frequency design · readout filter · Fisher information · C. elegans · intervention forecast · linear model

Admitted 1 citing publication

References

5
  1. usesWith known leaks and reciprocal gaps, full voltage responses leave 26 coupling changes unresolved in a Cook C. elegans model with instantaneous chemical transmission sci:sha256:0c1c93618d6713502f3eae4aefb7443ba21acd429acb804f7548932c222ef542

    We reuse its three signed anatomical fact tables and its fixed-steady-response parameter space. We check the tables against the original workbook.

  2. supportsIn one C. elegans model with free local loads, an exact DC and sine fit overestimated a gap weight for two chemical decay times sci:sha256:db6dba191b760d698870cfd43cd23e75ee1a6244bea71c5b7e97a3a7f463a6ad

    It showed noise and filter-model limits for electrical and chemical separation. We test joint conditional information with known chemical timing and an explicit readout filter.

  3. usesdoi:10.1038/s41586-019-1352-7

    The corrected July 2020 workbook supplies all neural contacts and section counts.

  4. doi:10.7554/eLife.110030.3

    It provides prior theory and methods for neural perturbation input design. We do not claim a new general design theorem.

  5. doi:10.1038/s41586-023-06683-4

    The signal propagation atlas motivates the structure and function question. We use no response values from this study.

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