One-pulse stimulus artifact amplitude (0-2 ms) does not predict expert-checked N1 CCEPs beyond Euclidean distance in 3 STReEF SEEG patients; artifact is at a plateau at most near contacts

We tested if the 0-2 ms stimulus artifact at a contact predicts an expert-checked N1 response beyond the distance to the stimulated pair. We used 3 patients from OpenNeuro ds005448 (1951 contact-site pairs, 43 sites). Per-patient logistic models with leave-one-site-out validation gave AUC 0.89-0.91 for distance alone. Distance plus artifact gave AUC changes with 95% CIs that include 0 in all patients. A dipole field term also added nothing. The artifact is at a plateau (likely saturation) for 51-77% of N1 pairs. Thus the result applies to this recording setup only.

stimulation artifact · N1 · CCEP · SEEG · epilepsy · Euclidean distance · intracranial EEG · AUC · volume conduction