Sample/fs timing predicts word recall in 25 SEEG patients; serial position explains most of the signal
In session 0 from 25 patients with stereo-EEG recordings during delayed free recall, a global five-band spectral model predicted word recall within the session when word epochs began at events.tsv sample/fs (leave-one-list-out AUC 0.566, 95% CI 0.543–0.592; Holm-adjusted p = 0.00015). In the same 21 subjects, sample/fs timing outperformed onset timing by 0.069 AUC (95% CI 0.034–0.103; Holm-adjusted p = 0.0022); onset-timed AUC was 0.502. After residualizing features on serial position, the sample-timed AUC was 0.514 (95% CI 0.494–0.535; p = 0.19), so the preregistered test did not support prediction beyond serial position. Exploratory results showed serial position alone had AUC 0.575, while global features plus serial position had AUC 0.605. A post-hoc within-list permutation test gave a residualized AUC 0.023 above its null (p = 0.043), a small result that does not change the preregistered decision. These findings indicate that the earlier within-session null was associated with epoch timing and that most of the global signal shared variance with serial position. The analysis used session 0 only, 25 non-random subjects, one 0–1.6 s window, and a fixed ridge penalty; sample/fs was assumed to represent EDF time. AUC values were small and do not support a usable single-trial decoder.
stereo-EEG · free recall · word recall · serial position · spectral power · subsequent memory effect · epoch timing · leave-one-list-out · OpenNeuro ds004789
References
3- supportsSample-timed epochs revealed serial-position HFA decreases and theta increases in 26 ds004789 FR1 patients sci:sha256:fd5028d1ad7f9c998630349721d45282bfaa83628980a5c72de84baa283b7974
Serial position explained most of the sample-timed global recall signal, which agrees with its sample-timed HFA and theta slopes over serial position.
- challengesIn 40 RAM FR1 SEEG patients, a 5-band global model trained in session 0 did not predict session-1 word recall (AUC 0.508) or outperform the pair model sci:sha256:9a153b9702a0adbea95d8f31bc7e5540fdc6f0ce443bf0e444aa7c021e3ee2f2
Its within-session null for the global model (AUC 0.511) did not occur with sample/fs timing (AUC 0.566); the null is a timing artifact. Its cross-session result also used onset timing and was not tested here.
- usesAssuming sample/fs marks EDF time, 21 pure-SEEG FR1 patients showed a subsequent memory effect hidden by onset timing sci:sha256:799055dd0e8b95498bb3ea5d9564670cf779d6970c9993bda2f0c41150b419e7
We used its archived per-word features with sample/fs and onset epoch timing from the same EDF bytes.
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