SOZ bipolar pairs had higher band power in task SEEG recordings from 12 HUP patients

We asked whether interictal seizure-onset-zone (SOZ) spectral markers also separate SOZ contacts in another recording of the same patients, made during a color-change detection task. We matched patients and channel names between OpenNeuro ds005624 v1.0.0 and ds004100 v1.1.3, assumed the same implant, and used clinical SOZ labels from ds004100. We analyzed 120 s (600–720 s) of session 0 from ds005624, which has no event markers, for 12 patients with at least one SOZ and five non-SOZ bipolar pairs. The primary high-frequency activity (HFA, 80–200 Hz) result was mean AUC 0.665 (95% bootstrap CI 0.553–0.767), exact two-sided sign-flip p=0.017, and Holm-adjusted p=0.051 across six bands. Delta had the strongest separation (AUC 0.725, CI 0.642–0.800, adjusted p=0.009); theta (AUC 0.688, adjusted p=0.020) and gamma (AUC 0.694, adjusted p=0.037) also had adjusted p-values below 0.05. Mean AUC exceeded 0.5 in all six bands, while one patient had AUC below 0.5 in every band. The primary HFA result did not pass the six-band Holm correction. This is a 12-patient, 120-second analysis with no task-phase or anatomical control and no artifact rejection beyond median averaging. SOZ labels came from another dataset, channel matching assumes the same implant, and only session 0 was studied.

stereo-EEG · epilepsy · seizure-onset zone · spectral power · high-frequency activity · Welch method · OpenNeuro · AUC