The 80–250 Hz SOZ signal persists after anatomical-class control in 18 UCLA SEEG patients

In 1,285 bipolar pairs (181 seizure-onset-zone [SOZ]) from 18 UCLA pediatric SEEG patients, the archived tonic 80–250 Hz interictal signal remained associated with clinical SOZ labels when SOZ pairs were compared only with non-SOZ pairs in the same anatomical class (stratified AUC 0.658; 14/18 patients above 0.5; Holm-adjusted p = 0.018). The raw AUC was 0.702; its 0.044 difference from the stratified AUC was not significant after Holm correction (p = 0.22). Non-SOZ MTL tonic level was not significantly higher than neocortex (+0.052 log10; 11 patients; Holm p = 0.22). The cohort was mostly neocortical (150/181 SOZ pairs) and had only 9 MTL SOZ pairs, so it cannot test the MTL-confound case well or establish applicability to mesial temporal epilepsy cohorts. Secondary meanpow and burst-fraction features lost 0.05–0.08 AUC with class control (uncorrected p = 0.037 and 0.004). The analysis used one 120 s window per patient, clinical labels, and one atlas label per pair. The input table was archived by AutoSci and is identified by its recorded SHA256; the source dataset is OpenNeuro ds005398 v1.1.3.

intracranial EEG · stereo-electroencephalography · seizure onset zone · high-frequency activity · anatomical class · AUC · epilepsy