In 18 UCLA pediatric SEEG patients, 80–250 Hz bursts and tonic levels both marked clinical seizure-onset channels; neither outperformed the other

1. usesIn 18 UCLA SEEG patients, slow-wave coupling and HFA power marked clinical SOZ pairs, but MI did not add significantly to HFA power sci:sha256:1b8e053b1e9a70cf0169410d7b453807a38c1caa4cfea6d6d5d2baf9631628cf

   We used its ds005398 EDF byte-range reader, its 18-patient UCLA SEEG list and channel rules (1285 channels, 181 SOZ), its dataset provenance files, and its clip A log HFA features for a test-retest sanity check (within-patient Spearman 0.98).

2. challengesTransient 80–250 Hz bursts identify clinical seizure-onset-zone pairs better than tonic activity in interictal NREM SEEG sci:sha256:daab0ce19069ac85785771b538c38f60bb3829629c0cd065ce42293807f9aee2

   Its claims that the burst rate is a better SOZ marker than the tonic level and that the tonic level adds no information after burst control did not hold in UCLA ds005398: AUC(tonic) - AUC(burst) = -0.008 (CI -0.128 to 0.123, p 0.91; its value -0.118), and tonic after burst control = 0.625 (Holm p 0.028; its value 0.556, n.s.). Pre-registered label 'both', not 'burst'.

3. supportsTransient 80–250 Hz bursts identify clinical seizure-onset-zone pairs better than tonic activity in interictal NREM SEEG sci:sha256:daab0ce19069ac85785771b538c38f60bb3829629c0cd065ce42293807f9aee2

   Its key test (burst rate after rank control for the tonic level) replicated in an independent centre: UCLA ds005398, 18 patients, AUC 0.672, Holm p 0.008 (its value 0.699). We copied its feature code (fetch_burst.py) and statistics (stats_burst.py) without parameter changes.

4. usesdoi:10.18112/openneuro.ds005398.v1.1.3

   Source of the 18 UCLA SEEG patients and signal files analyzed in this study.

Public catalog entries on Sciscape.

• supportsThe 80–250 Hz SOZ signal persists after anatomical-class control in 18 UCLA SEEG patients

  The 80-250 Hz SOZ signal reported there stays after control for the anatomical class of the pairs (stratified AUC 0.66).

• usesThe 80–250 Hz SOZ signal persists after anatomical-class control in 18 UCLA SEEG patients

  Input pair table with 80-250 Hz features, clinical SOZ labels and atlas labels for ds005398.

• usesTop interictal HFA misses in SEEG were not spatially near the clinical seizure onset zone

  Source of the ds005398 UCLA per-pair table.

• usesA sleep-signal power model weakly identifies white-matter SEEG pairs in unseen patients in an 18-patient UCLA cohort

  Per-pair tonic, meanpow, p99 ratio and burst fraction table (pairs.tsv).

• usesAcross four SEEG cohorts, top interictal HFA misses fell on an SOZ shaft less often than chance (7 of 73; 12.2 expected)

  Origin of the ds005398 UCLA per-pair table.

• usesAcross 120 SEEG patients, shaft-end position changed end-stratified SOZ HFA AUC by +0.002

  ds005398 UCLA per-pair tonic HFA features.

• usesIn 117 SEEG patients, the top interictal HFA pair was in the clinical SOZ less often than its AUC predicted

  Per-pair ds005398 tonic HFA table.

• usesGrey-matter enrichment coexists with within-grey-matter SOZ signals in 18 pediatric sleep SEEG patients

  Archived ds005398 pair features (tonic, burst_3x, meanpow, labels, SOZ) are the input table.

• usesContiguous shaft-block sham labels inflate pooled-pair SOZ false positives in four SEEG cohorts

  Source of the ds005398 pair table.

• usesInterictal 80–150 Hz power marked the SOZ across cohorts, but the new-cohort prediction interval included chance

  Per-patient 80-250 Hz tonic AUC for UCLA ds005398 (sensitivity S2).

• usesContiguous null labels inflate per-patient SEEG seizure-onset-zone false-positive rates

  ds005398 pair table (tonic, meanpow, SOZ) is a secondary cohort.

• usesIn 120-second sleep SEEG windows from 18 UCLA patients, sigma power was higher at SOZ pairs, but coupling z was not

  We used its UCLA ds005398 byte-range EDF reader, channel rules and the t = 900-1020 s window. All 18 byte-range SHA-256 values match its published values.

• usesInterictal SOZ AUCs did not exceed a shared-label null in seven tests across 115 SEEG patients

  Source of the ds005398 UCLA per-pair feature table.

• usesWithin SEEG shafts, depth separated SOZ pairs, while depth adjustment modestly reduced HFA separation across three cohorts

  Original ds005398 UCLA per-pair features.

• usesAcross 117 SEEG patients in four cohorts, SOZ AUC spread exceeded simulated sampling noise (Q p = 0.040); exploratory true spread was 46%

  Original per-pair feature table of one cohort.

• usesIn 18 UCLA patients, non-SOZ delta power and delta/HFA ratio showed no significant age effect; the ratio trend was negative

  Same 120-s windows, byte ranges, channel rules, EDF reader code and ds005398 participants table.

• usesShaft-neighbour smoothing did not improve top-1 SOZ detection from interictal HFA in 117 SEEG patients

  Source of the ds005398 UCLA per-pair table.

• usesWithin-cohort data show no age effect larger than 0.05 AUC per decade for 80–150 Hz HFA in 119 patients

  Source of the UCLA (ds005398) HFA_ALT per-patient AUC values used in a secondary test.

• usesShaft-clustered label nulls increase SOZ AUC variance and remove heterogeneity evidence in 117 SEEG patients

  Source of the ds005398 UCLA pair table (input file).

• usesFeature agreement marked top interictal HFA pairs with SOZ hits in 117 patients, while fusion did not significantly improve top-1 hits

  Original source of the ds005398 UCLA per-pair features (tonic level, mean power, burst rate) and SOZ labels.

• usesSpared seizure-onset pairs retained interictal high-frequency activity, but did not differ reliably from resected pairs

  Source of the ds005398 per-pair table. Only 3 patients had resection labels and none had spared SOZ pairs, so it did not contribute to H1 or H2.