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q-bio.NC · Neurons and Cognition

Within-cohort data show no age effect larger than 0.05 AUC per decade for 80–150 Hz HFA in 119 patients

This package tests whether per-patient seizure onset zone (SOZ) separation (AUC) of interictal high-frequency power changes with patient age. It uses archived AUC values for 119 patients in 9 public SEEG cohorts and ages from OpenNeuro participants.tsv files. The pre-registered test removes cohort means from age and AUC and permutes age within each cohort. The within-cohort slope is +0.001 AUC per 10 years (95% CI -0.035 to +0.035, permutation p 0.975). Broadband power, line length, and 80–250 Hz power also show no age effect (Holm p 1.0). Children (24) and adults (79) in the same cohorts do not have different HFA AUC values (difference -0.028, p 0.54). Only 6 patients are younger than 10 years; recording state differs between cohorts, and this test does not repeat feature extraction. The result applies to ages 0 to 62 years and depends on the clinical SOZ labels and archived per-patient AUC values being correct.

epilepsy · SEEG · interictal high-frequency activity · seizure onset zone · intracranial EEG · age · AUC · permutation test

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References

12
  1. usesIn 18 UCLA pediatric SEEG patients, 80–250 Hz bursts and tonic levels both marked clinical seizure-onset channels; neither outperformed the other sci:sha256:2e8119ca326b41f7ea7d9203153c75297ce6512a42fe05ac4177e59632e4f008

    Source of the UCLA (ds005398) HFA_ALT per-patient AUC values used in a secondary test.

  2. usesAmplitude features did not identify resected channels in 13 seizure-free Zurich iEEG patients, while marked fast ripples did sci:sha256:35207caed62d594f4eb6dee51d0203717e06f551132a3bc5e7defb2dfeaadedc

    Source of the ZUR (ds003498) per-patient AUC values in the input table.

  3. usesThe 30–45 Hz aperiodic exponent did not separate seizure-onset channels in 31 SEEG patients sci:sha256:970015c7ad657e77ac8f470146719405ea5536dba9b4dabf2cdf20f1f8c23615

    Source of the HUP (ds004100) per-patient AUC values in the input table.

  4. usesTransient 80–250 Hz bursts identify clinical seizure-onset-zone pairs better than tonic activity in interictal NREM SEEG sci:sha256:daab0ce19069ac85785771b538c38f60bb3829629c0cd065ce42293807f9aee2

    Source of the ds007118-20 per-patient AUC values in the input table.

  5. usesIn 43 SEEG patients, tonic 250–450 Hz power separated clinical SOZ pairs but did not outperform 80–150 Hz power sci:sha256:82353265d457c867bdfac4d9d341ed1e1b797df9bb949c3d83778c1db6f7643d

    Source of the ds007118-20 per-patient AUC values in the input table.

  6. usesInterictal 80–150 Hz power marked the SOZ across cohorts, but the new-cohort prediction interval included chance sci:sha256:93185a8bf74844484addd9abfd60b1346c4039ae874efe5c7a83d16359fcd3af

    The per-patient SOZ AUC table (results/patient_table.tsv) of this meta-analysis is the input of all tests.

  7. usesAcross 29 SEEG patients, the 30–45 Hz exponent did not separate SOZ channels, while four other features did sci:sha256:115bc8cb0b4c9e536b5f083843a2745508d3c6635a8156b661a9e084f51582a7

    Source of the JHU, MIAMI, NIH and UMF (ds003876) per-patient AUC values in the input table.

  8. usesdoi:10.18112/openneuro.ds004100.v1.1.3

    Source of participant ages used for the HUP cohort.

  9. usesdoi:10.18112/openneuro.ds003876.v1.0.2

    Source of participant ages used for JHU, MIAMI, NIH, and UMF cohorts.

  10. usesdoi:10.18112/openneuro.ds003498.v1.0.1

    Source of participant ages used for the ZUR cohort.

  11. usesdoi:10.18112/openneuro.ds007118.v1.0.0

    Source of participant ages used for DER, TMP, GE1, and GE2 cohorts.

  12. usesdoi:10.18112/openneuro.ds005398.v1.1.3

    Source of participant ages used for the UCLA cohort in the HFA_ALT secondary test.

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