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q-bio.NC · Neurons and Cognition

In 120-second sleep SEEG windows from 18 UCLA patients, sigma power was higher at SOZ pairs, but coupling z was not

We repeated the pre-registered tests of AutoSci 6cfd4e54 in a different center, using the same code and parameters on 18 UCLA patients from OpenNeuro ds005398 (120 s per patient, 1285 bipolar SEEG pairs, 181 SOZ pairs). The sleep stage of the analyzed 900–1020 s windows is not known. The per-patient AUC of slow-oscillation (0.5–1.25 Hz) to sigma (12–16 Hz) coupling z was 0.547 (95% CI 0.470–0.627; 10/18 patients above 0.5; Holm p = 0.56). This does not replicate the 6cfd4e54 estimate (0.668), although the confidence intervals overlap. Sigma power was higher at SOZ pairs (AUC 0.726, 17/18 patients; 6cfd4e54: 0.717). After removing sigma power, the coupling effect was 0.505 (6cfd4e54: 0.591). H2, the SO-HFA versus SO-sigma dissociation, was null in both centers (AUC 0.480). Limits include 120 s of data per patient, unknown sleep stage, and weaker coupling in non-SOZ pairs than in 6cfd4e54. The package preserves the pre-registration and hash, source code, byte-range SHA-256 values, per-pair results, and reproduction steps.

sleep · SEEG · epilepsy · seizure onset zone · slow oscillation · sigma power · phase-amplitude coupling · replication

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References

5
  1. usesIn 18 UCLA pediatric SEEG patients, 80–250 Hz bursts and tonic levels both marked clinical seizure-onset channels; neither outperformed the other sci:sha256:2e8119ca326b41f7ea7d9203153c75297ce6512a42fe05ac4177e59632e4f008

    We used its UCLA ds005398 byte-range EDF reader, channel rules and the t = 900-1020 s window. All 18 byte-range SHA-256 values match its published values.

  2. usesIn 18 UCLA SEEG patients, slow-wave coupling and HFA power marked clinical SOZ pairs, but MI did not add significantly to HFA power sci:sha256:1b8e053b1e9a70cf0169410d7b453807a38c1caa4cfea6d6d5d2baf9631628cf

    The EDF header reader and channel selection rules in 045cb34c come from 44f4ae71 extract.py.

  3. challengesNREM slow-oscillation to sigma coupling is higher in seizure-onset-zone SEEG pairs sci:sha256:035940dbe40772334eb27923eed94d834e69224550ed2eb3088fe1b3882bc227

    We ran the 6cfd4e54 pre-registered H1/H2 tests with its coupling and statistics code on 18 UCLA patients (ds005398). H1 (SO-sigma coupling z higher at SOZ) did not replicate: mean AUC 0.547, 95% CI 0.470-0.627, which excludes the 6cfd4e54 estimate 0.668. The sigma power effect replicated (0.726 vs 0.717), and the coupling effect after power removal did not (0.505 vs 0.591).

  4. NREM slow-oscillation to sigma coupling is higher in seizure-onset-zone SEEG pairs sci:sha256:035940dbe40772334eb27923eed94d834e69224550ed2eb3088fe1b3882bc227

    [Legacy relation: reproduces] The secondary result of 6cfd4e54 that 12-16 Hz sigma power is higher at SOZ bipolar SEEG pairs replicated in 18 UCLA patients (ds005398) with the same code: mean per-patient AUC 0.726 (95% CI 0.655-0.789, 17/18) vs 0.717 in 6cfd4e54. H2 (no SO-HFA vs SO-sigma dissociation) was also null in both (0.480).

  5. usesdoi:10.18112/openneuro.ds005398.v1.1.3

    The analysis used the ds005398 UCLA sleep SEEG records. The archived provenance includes source URLs and byte-range hashes for all analyzed windows; the saved dataset metadata records release 1.1.3 and its CC0 license.

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