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q-bio.NC · Neurons and Cognition

Spared seizure-onset pairs retained interictal high-frequency activity, but did not differ reliably from resected pairs

Across archived per-pair feature tables from four public SEEG datasets, we compared interictal high-frequency activity (HFA) in spared seizure-onset-zone (SOZ) pairs with resected SOZ pairs and spared non-SOZ pairs. In 20 patients with at least two pairs in each SOZ group, the mean patient-level AUC for resected versus spared SOZ HFA was 0.567 (95% CI 0.476–0.663; Holm-adjusted p=0.19), so the data did not show reliably lower HFA in spared pairs. In 49 patients, spared SOZ pairs had higher HFA than spared non-SOZ pairs (AUC 0.673, 95% CI 0.621–0.723; Holm-adjusted p=0.0001), similar to resected SOZ versus spared non-SOZ pairs (AUC 0.683 in 55 patients). The operated-patient-only H2 analysis, added after the first run, gave AUC 0.658 in 29 patients. Line length and spike rate also distinguished spared SOZ from spared non-SOZ pairs, but did not reliably distinguish resected from spared SOZ pairs. H1 had low power; labels were clinical, clips were approximately 90–120 seconds, reasons for sparing were unavailable, and surgical outcome was not used. The analyses used archived feature tables without new signal processing; ds005398 did not contribute to H1 or H2 because no included patient had a spared SOZ pair.

seizure-onset zone · stereo-EEG · interictal activity · high-frequency activity · epilepsy surgery · resection · AUC · clinical labels

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References

6
  1. usesIn 18 UCLA pediatric SEEG patients, 80–250 Hz bursts and tonic levels both marked clinical seizure-onset channels; neither outperformed the other sci:sha256:2e8119ca326b41f7ea7d9203153c75297ce6512a42fe05ac4177e59632e4f008

    Source of the ds005398 per-pair table. Only 3 patients had resection labels and none had spared SOZ pairs, so it did not contribute to H1 or H2.

  2. usesThe 30–45 Hz aperiodic exponent did not separate seizure-onset channels in 31 SEEG patients sci:sha256:970015c7ad657e77ac8f470146719405ea5536dba9b4dabf2cdf20f1f8c23615

    Source of the ds004100 per-pair table (logpow_hg_80_150, line_length, spike_rate, soz, resect labels) used for H1 and H2.

  3. usesIn 117 SEEG patients, the top interictal HFA pair was in the clinical SOZ less often than its AUC predicted sci:sha256:6c85dc6f3540bdd41aaeb79a7fbecee27e8b50ac476c990e8241c271ddd4e414

    We copied its 4 archived per-pair interictal feature tables (inputs/, same SHA-256) and used them as the only data. No new signal processing.

  4. supportsResected SOZ pairs had higher NREM features than resected non-SOZ pairs in 30 patients sci:sha256:e2a4e6e0f9de8b21689e1bc65587018d14d9221395c5170efb0019f759e7d942

    87bc519a showed that the SOZ HFA signal is not a general resection-zone effect (resected SOZ > resected non-SOZ). We found the complementary result: SOZ pairs outside the resection also had higher HFA than spared non-SOZ pairs (AUC 0.67), approximately equal to resected SOZ pairs.

  5. usesSlow-wave–HFA coupling and HFA power distinguish clinical SOZ depth pairs in 43 patients sci:sha256:9f9a03f5ae81593b8a29528c314db6efb6a4c1b7fb63e4d09e778c7b70330fe7

    Source of the ds007118/9/20 per-pair table (log_hfa 80-300 Hz, soz, resected labels) used for H1 and H2.

  6. usesAcross 29 SEEG patients, the 30–45 Hz exponent did not separate SOZ channels, while four other features did sci:sha256:115bc8cb0b4c9e536b5f083843a2745508d3c6635a8156b661a9e084f51582a7

    Source of the ds003876 per-pair table (logpow_hg_80_150, line_length, spike_rate, soz, resect labels) used for H1 and H2.

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