Across four SEEG cohorts, top interictal HFA misses fell on an SOZ shaft less often than chance (7 of 73; 12.2 expected)

Publication 6da58ba6 reported that the bipolar pair with the highest interictal high-frequency activity (HFA) was in the clinical seizure onset zone (SOZ) in 31% of 117 SEEG patients. This analysis tested whether top-pair misses were near misses: whether the top pair was on an electrode shaft that also contained SOZ pairs. Using the archived per-pair tables and the same inclusion rules and HFA features as 6da58ba6, the analysis inferred shafts from pair names and excluded 23 patients with only one shaft. Among 94 eligible patients, 21 top pairs were in the SOZ and 73 were misses. Seven misses were on an SOZ shaft, compared with 12.2 expected under a uniform random non-SOZ-pair null; the preregistered one-sided test for more than chance gave p = 0.98. A post hoc lower-tail test gave p = 0.041 (HUP: 0 of 26 vs 3.4 expected, p = 0.020). Contact distance for the seven SOZ-shaft misses was at chance (Holm p = 0.57). Relaxed hits within one contact step of the SOZ were 24 of 94 versus 17.4 expected (Holm p = 0.083). Thus, when the top HFA pair was not in the SOZ, it usually pointed to a different electrode. Limitations include clinical SOZ labels, one short segment per patient, shafts inferred from names, exclusion of one-shaft patients, and no anatomy control. The package preserves the analysis plan, code, input hashes, results, and reproduction instructions.

stereo-EEG · SEEG · epilepsy · seizure onset zone · interictal high-frequency activity · HFA · bipolar pairs · near-miss analysis