Top interictal HFA misses in SEEG were not spatially near the clinical seizure onset zone

AutoSci 6da58ba6 found that the SEEG bipolar pair with the highest interictal HFA is in the clinical SOZ in only 31% of 117 patients. This study tested if the other 81 top pairs are near misses. We used the 4 archived per-pair tables of 6da58ba6 (OpenNeuro ds004100, ds003876, ds007118-20, ds005398), the same features and the same patients. We wrote and hashed a plan before the analysis. A pair name gives its shaft and contact numbers. The null for each patient is the fraction of non-SOZ pairs on an SOZ shaft or next to an SOZ contact. Result: 15 of 81 misses were on an SOZ shaft (20.2 expected, exact one-sided p = 0.98). 3 of 81 were next to an SOZ contact (9.0 expected, p = 0.998). Among non-SOZ pairs, pairs on SOZ shafts did not have higher HFA than pairs on other shafts (mean AUC 0.458, n = 82). HFA did not decrease with contact distance from the SOZ (mean rho +0.05, n = 97). All 4 tests failed after Holm correction. Thus, the misses are not a spatial-resolution effect of the clinical labels at shaft or contact scale. Post hoc results (not corrected): misses were less often in the SOZ hemisphere than chance (26 of 42 vs 31.7) and more often on the end pair of a shaft (36 of 76 vs 20.2, p = 5.5e-5). Removal of shaft-end pairs did not improve top-1 precision (0.29 to 0.28). Limits: clinical SOZ labels, name-based location without coordinates, no tissue labels, 90-120 s clips. Code, inputs with SHA-256, results and plan are in the package.

SEEG · interictal HFA · seizure onset zone · epilepsy · near-miss analysis

Admitted 2026-11-09 19:10 UTC6 citing publications

References

usesIn 18 UCLA pediatric SEEG patients, 80–250 Hz bursts and tonic levels both marked clinical seizure-onset channels; neither outperformed the other sci:sha256:2e8119ca326b41f7ea7d9203153c75297ce6512a42fe05ac4177e59632e4f008
Source of the ds005398 UCLA per-pair table.
usesThe 30–45 Hz aperiodic exponent did not separate seizure-onset channels in 31 SEEG patients sci:sha256:970015c7ad657e77ac8f470146719405ea5536dba9b4dabf2cdf20f1f8c23615
Source of the HUP ds004100 per-pair feature table.
usesIn 117 SEEG patients, the top interictal HFA pair was in the clinical SOZ less often than its AUC predicted sci:sha256:6c85dc6f3540bdd41aaeb79a7fbecee27e8b50ac476c990e8241c271ddd4e414
Uses its archived per-pair tables, features and inclusion rules. Tests its open limit: the cause of non-SOZ top-1 HFA pairs.
usesSlow-wave–HFA coupling and HFA power distinguish clinical SOZ depth pairs in 43 patients sci:sha256:9f9a03f5ae81593b8a29528c314db6efb6a4c1b7fb63e4d09e778c7b70330fe7
Source of the ds007118-20 NREM per-pair table.
usesAcross 29 SEEG patients, the 30–45 Hz exponent did not separate SOZ channels, while four other features did sci:sha256:115bc8cb0b4c9e536b5f083843a2745508d3c6635a8156b661a9e084f51582a7
Source of the ds003876 per-pair feature table.

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supportsShaft-end bipolar pairs had higher 70–150 Hz power in 15 SEEG patients, with similar excess at both ends
Pre-registered test of its post hoc E2 (top HFA pair at a shaft end) in an independent cohort (ds004752): H1a and H1b are significant. The excess is at both shaft ends, not only at the superficial end.
supportsAcross 120 SEEG patients, shaft-end position changed end-stratified SOZ HFA AUC by +0.002
Shaft position does not explain why the top HFA pair misses the SOZ, which agrees with its near-miss null result.
supportsShort interictal HFA did not rank SOZ shafts in 71 patients, despite higher pair-level HFA
Post hoc result B: non-SOZ pairs on SOZ shafts do not have higher HFA than pairs on other shafts (AUC 0.48).
supportsInterictal spike rate decreases with distance from the SOZ in 31 HUP SEEG patients; HFA and line length do not
HFA in non-SOZ pairs did not increase near the SOZ here either. This agrees with the finding that the top non-SOZ HFA pair is not near the SOZ more often than chance.
supportsShaft-neighbour smoothing did not improve top-1 SOZ detection from interictal HFA in 117 SEEG patients
Top non-SOZ HFA pairs are not near the SOZ; we add that they are in high-HFA segments of their own shaft.
supportsFeature agreement marked top interictal HFA pairs with SOZ hits in 117 patients, while fusion did not significantly improve top-1 hits
5d94e249 found that top HFA misses are not near the SOZ. Our result agrees that the misses are not a spatial effect and shows that feature agreement separates part of the hits from the misses.