Two site rules showed no clear response contrast difference at 100 to 500 ms in seven SEEG patients

We compared two rules for choosing a brain stimulation site in public OpenNeuro ds004696 version 1.0.1 data from seven eligible SEEG patients. Both rules used five calibration pulses and a half target energy floor. One maximized target response fraction; the other maximized target response minus response on other recording shafts. The analysis included 20 candidate groups, 57 sites, and 216 target contexts. Five separate later pulses tested each choice at 100 to 500 ms. The mean normalized contrast difference was +0.00029 (descriptive 95% patient bootstrap interval -0.01879 to +0.02111); the two-sided sign flip reference was 1.00. The rules chose different sites in 21 contexts. This small offline comparison does not establish equivalent rules or functional brain control. Source contact selection was retrospective. Interpreting the cross-pulse product as mean response energy requires a stable response, zero mean error, and zero error covariance between distinct pulses; the data do not establish these assumptions.

SEEG · electrical brain stimulation · site selection · response contrast · pulse products · limbic system · OpenNeuro