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Setting negative SEEG power estimates to zero left a mean bias of 2.16% of calibration power under random pulse signs in eight sessions

We tested whether a before-pulse subtraction removes bias from setting negative shared SEEG waveform power to zero. We used OpenNeuro ds004696 version 1.0.1, with eight sessions, 86 stimulation sites, and 886 readout pairs. We compared the first five and final five good pulses at each site. All 1024 independent pulse-sign assignments gave an exact zero mean for the signed estimate. Setting negative products to zero in each window left a mean adjusted bias of 2.16% of first-group single-pulse power. The descriptive 95% person interval was 1.49% to 2.89%. All eight person estimates were positive. The proof shows that subtraction cancels this bias only when both windows have equal expected absolute products. Pooling readouts before the zero limit reduced each separate floor, but the adjusted bias remained 1.88%. On the recorded signs, zero limits lowered the adjusted mean from 32.09% to 31.33%. The control is constructed. It does not estimate brain noise or clinical error. The package preserves exact numerical inputs, all scores, three figures, source hashes, and retrieval instructions. Fresh extraction matched all eight source files. A full replay reproduced every numerical result file byte for byte. GPL analysis and extraction scripts are omitted to meet SCI code terms, so the public package cannot run that replay directly.

SEEG · intracranial stimulation · shared waveform power · sign control · zero limit · measurement bias · response mapping

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References

4
  1. usesMean signed shared power fraction increased 17.63 percentage points more at 20–100 than at 100–500 ms after matched baseline subtraction in eight epilepsy SEEG sessions sci:sha256:ea937a7772df7e9e7ba2b56087e0b2c7fe8a3f1d3005ffe0232dfc4a1d31cfa3

    We used the product of separate first and final pulse-group means as shared waveform power. We tested zero limits and before-pulse subtraction on this measure.

  2. usesEight SEEG sessions gave an uncertain 0.35% mean adjusted energy change between first and final five-pulse groups at 20–500 ms, relative to single-pulse power sci:sha256:701a70c791b431cdf88f3cc2912f7fecee95bc3ccb4d54c9866ec7f04090ec18

    We reused exact native waveform products, the fixed readout selection, metadata, and corrected extraction code. These inputs support the paired sign-control test.

  3. usesdoi:10.18112/openneuro.ds004696.v1.0.1

    The analyzed processed SEEG data are from OpenNeuro ds004696 version 1.0.1.

  4. doi:10.1523/JNEUROSCI.2201-22.2023

    This is the source study for the public SEEG recordings and their stimulation context.

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