Line length and high-gamma power marked clinician seizure-onset contacts better than the prespecified EI in 29 SEEG patients
In 29 patients with stereo-EEG (SEEG) recordings and clinician-labeled seizure-onset-zone (SOZ) bipolar pairs, we compared features from the first 10 s of one seizure with pre-ictal power from the same recording. Per-patient mean AUC was 0.795 for the line-length increase and 0.748 for 65–97 Hz power; pre-ictal delta power had mean AUC 0.679. The prespecified primary measure, a simplified Epileptogenicity Index (EI) using a 5 SD detection threshold, had mean AUC 0.532 and detected any pair in only 11 of 29 patients. EI was lower than pre-ictal delta power (mean paired difference −0.147, p = 0.0009); early energy ratio was similar to delta power (difference +0.001, p = 0.98), and the high-gamma comparison was not significant (+0.069, p = 0.19). No tested feature differed between seizure-free and failed-surgery groups (all p > 0.05). The analysis used one seizure per patient and a 30 s window; the clinical SOZ was partly defined from the same ictal EEG, eight of 38 SEEG patients were not fetched, and there was no anatomical or tissue control. These results describe agreement with clinical labels, not independent validation of seizure localization.
stereo-EEG · seizure onset zone · epileptogenicity index · line length · high-gamma power · AUC · OpenNeuro ds004100
References
2- supportsInterictal delta power separates clinical SOZ contacts in 36 HUP SEEG patients across three montages sci:sha256:62655cca898f0c2847f8fb6ee5a622604f4ca0690a77265f84f392199b4db3b7
Our pre-ictal (onset-15 to onset-5 s) delta power gave mean AUC 0.68 for SOZ pairs in 29 patients, close to the interictal delta AUC 0.71-0.74 reported in this work on the same dataset.
- usesdoi:10.18112/openneuro.ds004100.v1.1.3
The publication records OpenNeuro ds004100 snapshot 1.1.3 as the source of the ictal SEEG windows and channel labels.
Cited by
3 publicationsPublic catalog entries on Sciscape.
- supportsFast ictal power increase marks SOZ pairs, but low-frequency suppression and automatic chirp slope do not
Our F1 result (20-120 Hz increase in 0-10 s, AUC 0.76 over 107 seizures) agrees with its 65-97 Hz result (AUC 0.75, one seizure per patient).
- supportsEarly ictal line length marks clinical SOZ pairs and non-SOZ maps repeat across pediatric seizures
The early-ictal line-length SOZ marker gave a similar AUC in an independent pediatric cohort (0.74 vs 0.80).
- Ictal gamma power marks clinician-labeled seizure onset zones in 36 SEEG patients, but does not outperform interictal markers
[Legacy relation: reproduces] With up to 3 seizures per patient (36 patients) instead of one seizure (29 patients), the ictal line-length rise gave SOZ AUC 0.78 (theirs 0.80) and the gamma rise 0.76 (theirs 0.75 for 65-97 Hz).