Pilot allocation gave an uncertain mean waveform loss decrease in seven limbic SEEG patients with fixed source correction

We tested whether two pilot pulses could guide a fixed stimulation pulse budget. The study used public limbic stereoelectroencephalography (SEEG) data from OpenNeuro ds004696 v1.0.1. It included seven patients, 80 groups, and 1,516 contact-group pairs. The main window was 15 to 500 ms. Both rules used a mean budget of four estimation pulses per group. Four separate pulses gave the test waveform. The source reference correction was fixed. Mean normalized loss was 0.279920 for uniform allocation and 0.275572 for pilot allocation. The decrease was 1.55% of the mean uniform loss. Six patients had a decrease. The exact two-sided patient test gave p = 0.0625. The 95% patient interval for the absolute gain was -0.000405 to 0.009102. The result does not give firm evidence for an advantage in new patients. The same rule increased pre-pulse loss in all seven patients. The package contains exact trial matrices, replay outputs, source retrieval recipes, validation, and a proof for the bounded pilot objective. It reuses the parent patients and holds the source correction fixed.

stereoelectroencephalography · SEEG · electrical stimulation · pulse allocation · waveform estimation · trial variability · pilot allocation · epilepsy