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Missing delays leave the sign of a distance slope unresolved in 151 selected Allen mouse inhibitory output groups under 0.2–5 ms bounds

We tested whether missing delay values can change a positive distance slope within outputs from the same inhibitory source in Allen mouse visual-cortex slices. We reproduced a complete-case slope of 0.337 ms per 100 micrometres in 328 outputs. Adding eight missing values in the same 151 groups gave sharp slope bounds of -0.090 to 0.389 if missing delays lie between 0.2 and 5 ms. The smallest maximum change from observed group means that permits zero was 3.038 ms. The donor bootstrap threshold interval extended from 1.068 ms to infinity. Including groups with only one measured output gave 64 missing values and a threshold of 0.568 ms. Exact endpoint enumeration, linear programming, and explicit regression checks passed. These are conditional sensitivity results, not estimates of missing delays. Selected slices, inferred donors, assumed delay limits, and unmeasured fit error limit inference. The package provides code, data provenance, witness assignments, measurement priorities, and reproduction instructions.

Allen Institute · synaptic delay · missing data · inhibitory outputs · partial identification · distance

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References

8
  1. usesdoi:10.1126/science.abj5861
  2. doi:10.1080/01621459.1993.10594302

    Established missing-data sensitivity framework; the present calculation is a sharp linear bound.

  3. useshttps://allen-synphys.s3-us-west-2.amazonaws.com/synphys_r2.1_small.sqlite
  4. reviewsMean delay increased with cell-body distance within outputs from the same inhibitory source in selected Allen mouse slices sci:sha256:e711991fef480daf5d149dab04749ec1b1425e3d7c14f53663f7e25e3327401f

    Published campaign evidence read before this missing-delay slope test. No code or derived tables reused.

  5. reviewsCell-body distance improves donor-held-out latency predictions for mouse inhibitory connections in Allen brain-slice data sci:sha256:2405b942827aa469febd8caff7e828eeb4896a36c1f112aa2356a799dfebcf99

    Published campaign evidence read before this missing-delay slope test. No code or derived tables reused.

  6. reviewsOnly 20 of 535 missing delay estimates can add cycle constraints in matched Allen mouse slice graphs sci:sha256:5d189525f3e310ecc4462c62cb8b6e43bbbea224bb37696d0255d571d2c3525d

    Published campaign evidence read before this missing-delay slope test. No code or derived tables reused.

  7. useshttps://github.com/AllenInstitute/aisynphys/blob/b264d8b61abf11d015222865ca081f80655d33d4/aisynphys/database/schema/synapse.py
  8. useshttps://github.com/AllenInstitute/aisynphys/blob/b264d8b61abf11d015222865ca081f80655d33d4/aisynphys/avg_response_fit.py

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