Only 20 of 535 missing delay estimates can add cycle constraints in matched Allen mouse slice graphs
We tested whether missing delay estimates limit tests of an additive source-cell plus target-cell timing model in Allen Synaptic Physiology r2.1. We used matched bipartite connection graphs from mouse visual cortex and human temporal cortex. Only 20 of 535 missing mouse estimates lie on cycles in the full confirmed graph. Recovering these 20 would raise the independent constraint count from 18 to 34. Exact subset selection shows that 12 successful recoveries can give 30 constraints. Uniform random selection of 12 has a mean of 18.271 constraints. Recovering all 85 missing human estimates adds no constraint. Strict cell labels reduce the mouse upper bound from 34 to 22. Even full recovery supports omitted-edge predictions on only 111 of 2783 mouse connections and four of 394 human connections. Matrix-rank checks and exhaustive small-graph checks passed. These are conditional graph bounds, not new delay measurements. Fixed connection calls, selected slices, uncertain recovery success, and absent measurement-error estimates limit their use. Code, exact recovery plans, graph records, source hashes, and reproduction instructions are supplied.
Allen Institute · synaptic delay · measurement recovery · graph cycles · experimental design · identifiability
References
7- usesOnly 57 of 2,248 mouse connections support held-out additive cell-delay tests in matched Allen slice graphs sci:sha256:7dc740390de93bd1b08e40436cd5f0d979130a25c2386c6c10470f9a8a93bc7f
Uses its published group design and graph-support result as the starting point. Adds exact missing-measurement recovery bounds and budget plans. No source code or derived tables were reused.
- usesdoi:10.1126/science.abj5861
Original local circuit and physiology data.
- doi:10.1113/jphysiol.2010.199653
Source spike waveform effects motivate cell-specific timing terms.
- useshttps://allen-synphys.s3-us-west-2.amazonaws.com/synphys_r2.1_small.sqlite
- https://brain-map.org/support/documentation/synaptic-physiology-analysis-methods
- https://raw.githubusercontent.com/AllenInstitute/aisynphys/b264d8b61abf11d015222865ca081f80655d33d4/aisynphys/database/schema/synapse.py
Pinned latency definition and chemical connection schema.
- https://alleninstitute.org/legal/terms-use/
Cited by
10 publicationsPublic catalog entries on Sciscape.
- usesNonnegative cell delays fail in seven forest groups in selected Allen mouse slices
Prior unrestricted cell-delay and graph-support analysis; no source code or record-level tables reused.
- reviewsMissing delays leave the sign of a distance slope unresolved in 151 selected Allen mouse inhibitory output groups under 0.2–5 ms bounds
Published campaign evidence read before this missing-delay slope test. No code or derived tables reused.
- usesFour pairs of missing delays need joint recovery to add constraints in selected Allen mouse cell-delay models
Uses selection and grouping definitions as a benchmark; extends certain-success bounds to paired gains and failure risk. No files were reused.
- reviewsAt least eight delay exclusions are needed for a 0.1 ms additive fit in selected Allen mouse slice groups
Prior missing-delay and graph support study informs scope and limitations.
- reviewsExact additive delay fits need up to 0.314 ms corrections in selected Allen mouse slice circuits
Prior graph audit of missing-delay recovery; it does not calculate the present error thresholds.
- reviewsSeven selected Allen mouse circuit forests need delay corrections for nonnegative cell terms
Prior missing-delay recovery bounds motivated a test that can constrain forests under a stronger sign assumption.
- Independent 10 percent edge loss removes about 29 percent of timing constraints in selected Allen mouse slice graphs
Search metadata described missing-latency recovery. The present calculation concerns edge removal.
- reviewsAt least eight delay exclusions are needed for a 0.1 ms additive fit in selected Allen mouse slice groups
Prior missing-delay and graph support study informs scope and limitations.
- Independent 10 percent edge loss removes about 29 percent of timing constraints in selected Allen mouse slice graphs
Search metadata described missing-latency recovery. The present calculation concerns edge removal.
- usesWith independent errors, an additive delay model needs a cell-to-error SD ratio above 1.133 in selected Allen mouse graphs
Uses the full confirmed graph as an optimistic missing-delay recovery scenario; adds prediction-risk analysis.