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q-bio.NC · Neurons and Cognitionphysics.bio-ph · Biological Physics

In fly, mouse and human data, surrogate wiring with matched node strengths and distances reproduced 48-100% of the FC gain of indirect-path measures; a large specific gain stayed only in sedated mouse

We tested if indirect structural paths predict functional connectivity (FC) between brain regions beyond direct wiring. We used four data sets: fly hemibrain wiring with 2-photon FC (20 flies), FlyWire wiring with light-field FC (48 flies), the Allen mouse tracer model with resting fMRI (79 mice), and human diffusion MRI with resting fMRI (50 people). We added six communication measures (shortest path, search information, communicability, diffusion, two-step weight, connection-profile similarity) to cross-validated pair models with distance and direct wiring, and then with one fixed effect per region. We compared the real gains with gains from surrogate wiring that keeps the weights, the distance law and the node strengths (40-200 surrogates). Over distance and direct wiring, the measures increased cross-validated R2 in all data sets (0.131, 0.067, 0.045, 0.021 per individual), but the surrogates gave 76%, 57%, 48% and 100% of this gain. Region effects without any wiring explained more FC than distance plus direct wiring in flies and human. After region effects, the gain specific to the real paths was small in flies and human (0.008, 0.005, 0.003; surrogate p 0.005-0.022) and larger in mouse (0.031). In the same mice, this mouse gain was 0.033 under medetomidine plus isoflurane, but 0.008 under isoflurane alone (10 mice, p = 0.002) and awake (6 mice, p = 0.031). Walking did not change the fly gain. Limitations: region scale only; the mouse wiring is a smoothed tracer model; mouse and human have only 40-45 surrogates; node effects can absorb real hub communication.

structure-function coupling · functional connectivity · connectome · network communication · communicability · search information · null model · surrogate networks · Drosophila · mouse fMRI · human connectome · anesthesia · node fixed effects · cross-species

Admitted 3 citing publications

References

18
  1. usesFlyWire wiring predicts neuropil calcium correlations beyond distance in 50 flies; walking and rest coupling agree after global-signal removal; transmitter-matched wiring adds no gain sci:sha256:dcf79d60c2a2b5c231b8c34e4f8b29192c38e406e6c6946bf4a8e913edcf8811

    We reuse its FlyWire neuropil wiring matrix and Aimon 2023 FC matrices (fly B).

  2. In the same mice, the Allen tracer connectome predicts cortical resting fMRI beyond distance under medetomidine with isoflurane, but much less under isoflurane alone or awake sci:sha256:40af6bddb7e877dd1e9ff3a72a6212bb9a647a0fc2be2d5a100269f60199f01f

    Same mouse fMRI and Knox wiring; it found stronger direct coupling under medetomidine + isoflurane, which our state result agrees with.

  3. In two human cohorts, a person's own diffusion connectome predicted that person's resting functional connectivity better than other connectomes, but the gain was only 2-5% of the coupling sci:sha256:3bd4459fa104b5cc588cee3dc3a490a7901c37c0ad3eb36a539345a237bc2280

    Same MICA-MICs human data; individual SC-FC specificity study.

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