Soma distance gave no clear linear change in the response similarity effect in one MICrONS connection model

We tested whether soma distance changes the link between measured movie response similarity and synaptic connection in the public MICrONS v1 tables. The sample had 295,371 candidate pairs and 8,128 connections from one mouse. The primary Poisson mean model had separate source and target cell effects and controls for anatomical opportunity and cell types. It used 163,870 informative pairs. The similarity by log distance coefficient was -0.0067, with a nominal 95% dyadic interval of -0.0260 to 0.0127. From 105 to 566 micrometres, the ratio of the two similarity mean ratios was 0.983, with interval 0.934 to 1.034. The primary test does not resolve a linear distance change. It does not establish distance independence. One mouse, selected axons, response measurement error, incomplete geometry controls, and model form limit the result. Code, selected pair data, source hashes, numerical checks, and a figure support reproduction.

MICrONS · Allen Institute · soma distance · response similarity · neuron fixed effects · structure and function · null result