Dendrite orientation gave negative linear slopes for inhibitory rise time within six mouse cerebellar cells

We tested whether dendrite direction helps explain inhibitory current timing within the same mouse cerebellar nuclear cell. A released table from Gruver et al. (2024) has 28 input records from 14 cell IDs. Six cells have different orientation values and supply 19 records. All six had negative linear slopes for raw and natural log rise time. The pooled raw correlation was 0.006. A common cell-intercept model gave a raw slope of -1.502 ms per unit orientation fraction and a log slope of -0.974. We counted all 7,776 arrangements of orientation labels within cells. Two-sided probabilities were 0.122 for raw time and 0.046 for log time. Neither passed Holm correction across raw and log time and amplitude; the smallest adjusted probability was 0.184. Rank correlations were negative in four cells and zero in two. Slopes stayed negative when any cell or date-code group was removed. In an added conditional prediction check, a slope fitted in other cells reduced mean log time test error by 42.8% across six cells. Other input responses of the test cell supplied its baseline. This is not prediction of a wholly unmeasured cell. The result is exploratory. Input labels, trial errors, and linked animal IDs are absent. The data do not locate synapses or identify a timing mechanism. The package preserves source files, cell addresses, all tests and reference scores, predictions, figures, new code, and offline repeat instructions. Independent workbook parsing, rational arithmetic, explicit cell-intercept fits, and a clean replay checked the results.

cerebellum · dendrite orientation · inhibitory current · within-cell comparison · exact permutation test · structure and function