Per-channel slow-oscillation phase targets gave a small simulated ripple gain, while a fixed group target gave none
We tested whether a causal slow-oscillation (SO) phase trigger could place simulated pulses in author-marked ripple windows during NREM sleep, and whether the target phase needed channel-specific calibration. In OpenNeuro ds003498 data named as version 1.0.1, we analyzed run-01's first 200 s for 455 bipolar SEEG pairs from 19 patients. We calibrated on 0–100 s and evaluated on 100–200 s. With a 100 ms pulse latency, the patient-level geometric-mean ripple rate ratio was 1.069 for the per-channel calibrated phase bin, 1.022 for an amplitude gate alone, and 1.022 for a group bin selected from other patients. The per-channel versus gate difference was about 4.6% (one-sided sign-flip p = 0.037); the per-channel versus group difference was not significant (p = 0.076). Neither primary comparison passed the two-test Holm correction. At zero latency, neither comparison was significant. Ripple preferred phases varied across channels, and the calibrated bin matched the test-half best bin in 10% of pairs, near the 8.3% chance level. This was a simulation without stimulation; author-marked ripples were used, and only one 200 s run per patient was analyzed. The per-channel result is small and does not establish a stimulation benefit.
slow oscillation · ripple · SEEG · NREM sleep · closed-loop simulation · phase targeting · signal processing
References
4- usesA calibrated constant offset matched frequency-advanced ecHT for 100 ms SO-phase prediction in held-out SEEG from 6 patients sci:sha256:31390a079878af8b389f531ba3e5ef209dfd61489ebaa951fbba42b31d582281
It gives the 100 ms stimulation latency and the causal SO phase error on ds003498 that our trigger simulation assumes.
- usesIn 12 SEEG patients, AR(20) had larger slow-oscillation phase errors than calibrated Hilbert hold at 100 ms sci:sha256:ca0bb212fdd25c594bec6d3c5556f572ef6d90ae7ee6129a02c4ad0a049a843c
We used its E1-hold causal SO phase method (4 s window, FFT band-pass 0.5-2 Hz, Hilbert, last-sample hold) and its byte-range retrieval recipe for ds003498.
- usesCausal ripple triggers fired later and left less ripple time than offline detection sci:sha256:b8c3c650af1ad1b3f69fe9616a4bcbf0f61b64df825f2a6aae4e3bfdfbb5f999
It uses the same author ripple marks of ds003498 as the reference. We test SO-phase timing as an alternative route to ripple-locked stimulation.
- usesdoi:10.18112/openneuro.ds003498.v1.0.1
The publication identifies OpenNeuro ds003498 v1.0.1 as the source dataset. The acquisition manifest records the S3 mirror URL and SHA-256 hashes for the analyzed byte ranges and associated metadata files; equality with the immutable DOI snapshot was not independently established.
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