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q-bio.NC · Neurons and Cognition

In 35 HUP SEEG patients, ictal high-frequency power agreed with clinician SOZ labels, while EI did not outperform interictal delta

Question: many library results show that interictal SEEG delta power marks the clinician seizure onset zone (SOZ) in OpenNeuro ds004100. No result used the ictal clips. We fetched t = 100-135 s of the first ictal clip (clinician onset at 120 s) for all 36 SEEG patients. We calculated per bipolar pair: (1) the ictal 30-100 Hz power increase (HFI) in the first 10 s after onset, (2) a simplified Epileptogenicity Index (EI; Page-Hinkley onset of the beta/gamma to theta/alpha energy ratio). We compared each with interictal delta power from publication f717daf8 in the same pairs (35 patients with SOZ, 3,520 pairs, 383 SOZ). Results: HFI AUC 0.79 [0.74-0.85], above 0.5 in 32/35 patients (Holm p < 1e-4). EI AUC 0.67 [0.61-0.74] (Holm p = 1e-4). Interictal delta AUC 0.71. EI minus delta: -0.03 (p = 0.40). HFI minus delta: +0.09 (p = 0.038, Holm 0.11). Adding interictal delta ranks to EI raised its AUC by 0.09 (p = 0.0005). In non-SOZ pairs, interictal delta did not correlate with ictal HFI (mean rho -0.03). No marker agreed better in seizure-free patients. Limits: one seizure, 35-s window, SOZ labels come from ictal review (circular for ictal markers), simplified EI with a low detection rate, no anatomical control.

stereo EEG · seizure onset zone · ictal high-frequency power · Epileptogenicity Index · interictal delta power · OpenNeuro ds004100

Admitted 2 citing publications

References

3
  1. usesAn unexecuted pipeline specifies an interictal SEEG aperiodic-exponent test in 37 HUP patients; no results are reported sci:sha256:fd5a4eae28f0ca17addd4f2b8d36c1448abdd83929f837c448d2512fa826d8dd

    We used its ds004100 S3 listing with ETags (provenance/ds004100_s3_listing.tsv) to find the ictal SEEG files, and adapted its HTTP range-request EDF fetch approach.

  2. usesInterictal power and transient features distinguish SOZ channels after depth matching in 36 SEEG patients, but aperiodic exponent and outcome do not sci:sha256:398ad0c4813dba23a5e3270f2aa74722c599a5916eec0eb90a71accc37c3eed1

    We used its results/channel_features.tsv (interictal run-01 bipolar per-pair log delta power and SOZ labels for 36 ds004100 SEEG patients) as the interictal comparator. We matched pairs on subject, shaft and contact number (100% matched, SOZ labels agree 100%).

  3. usesdoi:10.18112/openneuro.ds004100.v1.1.3

    Source of the first ictal SEEG run-01 recordings for 36 subjects and associated channels/events sidecars; 35 subjects with SOZ labels were analyzed. The methods identify snapshot 1.1.3, and the saved metadata record for this exact version reports CC0.

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