Early thalamic line length did not track seizure duration within 12 patients in ds007445

We tested whether early ictal activity in the ipsilateral thalamus relates to seizure duration within patients, using archived bipolar log line-length series from OpenNeuro ds007445 (1-s bins). For each seizure, we calculated the mean pairwise z-score in the first 10 s after annotated onset against a −60 to −10 s baseline, then calculated within-patient Spearman correlations between this measure and log seizure duration. Across 12 patients, the mean thalamic rho was 0.00 (95% bootstrap CI −0.33 to 0.33; 6 positive and 6 negative; exact sign-flip p = 1.00). The thalamus minus white-matter difference was +0.23 (CI 0.00 to 0.50; n = 11; p = 0.25, Holm-adjusted p = 0.50). White matter, non-SOZ cortex, and SOZ correlations were −0.17, −0.08, and −0.25 (all p > 0.3). Results were also null for 5-s and 20-s windows. A secondary binary recruitment measure was negatively associated with duration in all regions, so it was not thalamus-specific. The findings provide no evidence of a relation in this analysis; with only three eligible seizures per patient, power was low and a moderate relation cannot be excluded. Event timing and region labels rely on dataset annotations, and one split seizure file was treated as a single seizure.

seizure duration · thalamus · stereo-EEG · line length · within-patient analysis · epilepsy