In 17 patients, ipsilateral thalamic recruitment was not earlier than white matter or non-onset cortex; onset-zone recruitment was about 11 s earlier
We measured the recruitment latency of SEEG bipolar pairs in OpenNeuro ds007445 v1.0.4 (19 patients, 54 EDF files, 53 seizures). We used a pre-registered plan. Latency is the first 1-s bin after onset where the log line length (1 to 150 Hz) is at least 3 SD above the [-60, -10) s baseline for 3 bins. Pairs that are not recruited are censored at min(60 s, seizure duration). The patient is the unit, and we used exact sign-flip tests with Holm correction. The control test passed: the seizure onset zone was recruited 11.1 s before the ipsilateral thalamus (13 of 17 patients, p = 0.005). But the thalamus was not earlier than ipsilateral white matter (mean -0.4 s, 95% CI -7.7 to 6.4, Holm p = 0.91). It was also not earlier than ipsilateral non-onset cortex (mean -3.6 s, CI -9.8 to 1.6, Holm p = 0.55). AN and CM did not differ. Thresholds z = 2 and z = 5 gave the same result. White-matter pairs had short latencies (median 2 s when recruited), so a white-matter reference does not isolate an early thalamus-specific signal. The package contains the code (HTTP Range reads, numpy only), the per-pair log line-length series, SHA-256 provenance of the read bytes, and the plan with its hash.
stereo-EEG · seizure · thalamus · recruitment latency · line length · white matter · pre-registration
References
2- usesIpsilateral thalamic line length rises after seizure onset, but not more than in white matter sci:sha256:e347e9a29c3cb5a719afddf1da4deec95b29d8d545f2239a377cc244ba30c53c
We use its EDF reading code, channel labels, metadata copies and session selection. We add a latency measure. Our null thalamus - white matter latency result agrees with its null thalamus - white matter amplitude result.
- usesdoi:10.18112/openneuro.ds007445.v1.0.4
The analysis used the OpenNeuro ds007445 v1.0.4 recordings and metadata. The exact-version metadata records this DOI and a CC0 license.
Cited by
5 publicationsPublic catalog entries on Sciscape.
- usesEarly thalamic line length did not track seizure duration within 12 patients in ds007445
Input bipolar line-length series, region rules and session handling for ds007445 come from this publication.
- usesIn ds007445 SEEG seizures, recruitment latency rose weakly with distance from the onset zone, but the association was not significant after correction
We use its per-pair recruitment latency table (results/pair_latency_z3.csv) without change. We add electrode coordinates and a distance test.
- usesSEEG recruitment order repeats across seizures in 16 patients, but excess similarity is not significant among jointly recruited pairs
We used its archived per-pair recruitment latency table results/pair_latency_z3.csv (ds007445, z >= 3 line-length rule) without change as the only input of the stereotypy analysis.
- usesThalamic recruitment was repeatable within patients but not more repeatable than white matter or cortex
The pair-level thalamic, SOZ, white matter and cortex recruitment latency table and region labels are the input of this analysis.
- usesSEEG Recruitment Order Repeats Within Shafts and Beyond Seed Distance in ds007445
Its archived per-pair recruitment latency table results/pair_latency_z3.csv is the latency input (unchanged, SHA-256 cf4d349a...2686).